Translating phage therapy into the clinic: Recent accomplishments but continuing challenges

A Petrovic Fabijan, J Iredell, K Danis-Wlodarczyk… - Plos …, 2023 - journals.plos.org
Phage therapy is a medical form of biological control of bacterial infections, one that uses
naturally occurring viruses, called bacteriophages or phages, as antibacterial agents …

Biological foundations of successful bacteriophage therapy

C Venturini, A Petrovic Fabijan… - EMBO Molecular …, 2022 - embopress.org
Bacteriophages (phages) are selective viral predators of bacteria. Abundant and ubiquitous
in nature, phages can be used to treat bacterial infections (phage therapy), including …

Evaluation of the impact of repeated intravenous phage doses on mammalian host–phage interactions

X Tan, K Chen, Z Jiang, Z Liu, S Wang, Y Ying… - Journal of …, 2024 - Am Soc Microbiol
Phage therapy has shown great promise for the treatment of multidrug-resistant bacterial
infections. However, the lack of a thorough and organized understanding of phage–body …

Isolation of Klebsiella pneumoniae Phage vB_KpnS_MK54 and Pathological Assessment of Endolysin in the Treatment of Pneumonia Mice Model

B Lu, X Yao, G Han, Z Luo, J Zhang, K Yong… - Frontiers in …, 2022 - frontiersin.org
With the improper use of antibiotics, an increasing number of multidrug-resistant bacteria
have been reported worldwide, posing challenges for disease treatment. Klebsiella …

Characterization of novel bacteriophage PSKP16 and its therapeutic potential against β-lactamase and biofilm producer strain of K2-Hypervirulent Klebsiella …

S Rahimi, M Bakht, A Javadi, F Foroughi… - BMC microbiology, 2023 - Springer
Background Severe infections caused by β-lactamase producers, hypervirulent Klebsiella
pneumoniae (BhvKp) with K2 serotype, highlight emergency need for new therapeutic …

Biological analysis of phage vB_AhaP_PT2 and treatment rescued crucian carp infected with Aeromonas hydrophila

S Liang, R Liang, SHA Raza, Q Huang, T Li, H Bai… - Aquaculture, 2025 - Elsevier
Phage therapy is an alternative approach to overcoming the problem of multidrug resistance
in bacteria. In this study, we isolated and purified a virulent phage named vB_AhaP_PT2 …

Phage-specific antibodies: are they a hurdle for the success of phage therapy?

A Washizaki, A Sakiyama, H Ando - Essays in Biochemistry, 2024 - portlandpress.com
Phage therapy has attracted attention again owing to the increasing number of drug-
resistant bacteria. Although the efficacy of phage therapy has been reported, numerous …

Bacteriophage protein Dap1 regulates evasion of antiphage immunity and Pseudomonas aeruginosa virulence impacting phage therapy in mice

S Le, L Wei, J Wang, F Tian, Q Yang, J Zhao… - Nature …, 2024 - nature.com
Bacteriophages have evolved diverse strategies to overcome host defence mechanisms and
to redirect host metabolism to ensure successful propagation. Here we identify a phage …

Ciprofloxacin in combination with bacteriophage cocktails against multi-drug resistant Pseudomonas aeruginosa in ex vivo simulated endocardial vegetation models

A El Ghali, K Stamper, AJ Kunz Coyne… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
Pseudomonas aeruginosa-associated infective endocarditis represents difficult-to-treat,
deep-seated infections. Phage-antibiotic combinations have shown to eradicate multi-drug …

Bacteriophages and Their Host Range in Multidrug-Resistant Bacterial Disease Treatment

KM Chung, XL Liau, SS Tang - Pharmaceuticals, 2023 - mdpi.com
The rapid emergence of multidrug-resistant (MDR) bacteria in recent times has prompted the
search for new and more potent antibiotics. Bacteriophages (commonly known as phages) …