The fruit fly, Drosophila melanogaster, has a long and rich history as an important model
organism for biologists. In particular, study of the fruit fly has been essential to much of our …

RNA helicases unwind their RNA substrates in an ATP-dependent reaction, and are central
to all cellular processes involving RNA. They have important roles in viral life cycles, where …

DEAD-box RNA helicases play various, often critical, roles in all processes where RNAs are
involved. Members of this family of proteins are linked to human disease, including cancer …

Abstract Gemins 2–8 and Unr‐interacting protein (UNRIP) are intimate partners of the
survival motor neuron (SMN) protein, which is the determining factor for the neuromuscular …

Not many scientific breakthroughs bring significant advances simultaneously in both basic
research and translational applications like the discovery of RNA interference. Along with …

RNA-binding proteins (RBPs) play a pivotal role in the lifespan of RNAs. The disfunction of
RBPs is frequently the cause of cell disorders which are incompatible with life. Furthermore …

Spinal muscular atrophy (SMA), the leading genetic cause of infant mortality, is
characterized by the degeneration of spinal motor neurons and muscle atrophy. Although …

DEAD-box decapping enzyme 20 (DDX20) is a putative RNA-decapping enzyme that can
be identified by the conserved motif Asp–Glu–Ala–Asp (DEAD). Cellular processes involve …

The Epstein-Barr nuclear antigen 3C (EBNA3C), one of the essential latent antigens for
Epstein-Barr virus (EBV)-induced immortalization of primary human B lymphocytes in vitro …

RNA interference (RNAi) technology has been used in the development of approaches for
pest control. The presence of some essential genes, the so-called “core genes,” in the RNAi …