FtsZ dynamics in bacterial division: What, how, and why?

JM Barrows, ED Goley - Current opinion in cell biology, 2021 - Elsevier
Bacterial cell division is orchestrated by the divisome, a protein complex centered on the
tubulin homolog FtsZ. FtsZ polymerizes into a dynamic ring that defines the division site …

Localization, assembly, and activation of the Escherichia coli cell division machinery

PA Levin, A Janakiraman - EcoSal Plus, 2021 - Am Soc Microbiol
Decades of research, much of it in Escherichia coli, have yielded a wealth of insight into
bacterial cell division. Here, we provide an overview of the E. coli division machinery with an …

Biomolecular condensate drives polymerization and bundling of the bacterial tubulin FtsZ to regulate cell division

B Ramm, D Schumacher, A Harms, T Heermann… - Nature …, 2023 - nature.com
Cell division is spatiotemporally precisely regulated, but the underlying mechanisms are
incompletely understood. In the social bacterium Myxococcus xanthus, the …

FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in Bacillus subtilis cell division

KD Whitley, C Jukes, N Tregidgo, E Karinou… - Nature …, 2021 - nature.com
Despite the central role of division in bacterial physiology, how division proteins work
together as a nanoscale machine to divide the cell remains poorly understood. Cell division …

Cell-free biogenesis of bacterial division proto-rings that can constrict liposomes

E Godino, JN López, I Zarguit, A Doerr… - Communications …, 2020 - nature.com
A major challenge towards the realization of an autonomous synthetic cell resides in the
encoding of a division machinery in a genetic programme. In the bacterial cell cycle, the …

Self-organization of mortal filaments and its role in bacterial division ring formation

C Vanhille-Campos, KD Whitley, P Radler, M Loose… - Nature Physics, 2024 - nature.com
Filaments in the cell commonly treadmill. Driven by energy consumption, they grow on one
end while shrinking on the other, causing filaments to appear motile even though individual …

Single-molecule imaging reveals that Z-ring condensation is essential for cell division in Bacillus subtilis

GR Squyres, MJ Holmes, SR Barger… - Nature …, 2021 - nature.com
Although many components of the cell division machinery in bacteria have been identified,,
the mechanisms by which they work together to divide the cell remain poorly understood …

Chiral and nematic phases of flexible active filaments

Z Dunajova, BP Mateu, P Radler, K Lim, D Brandis… - Nature Physics, 2023 - nature.com
The emergence of large-scale order in self-organized systems relies on local interactions
between individual components. During bacterial cell division, FtsZ—a prokaryotic …

Bacterial division ring stabilizing ZapA versus destabilizing SlmA modulate FtsZ switching between biomolecular condensates and polymers

B Monterroso, MÁ Robles-Ramos… - Open …, 2023 - royalsocietypublishing.org
Cytokinesis is a fundamental process for bacterial survival and proliferation, involving the
formation of a ring by filaments of the GTPase FtsZ, spatio-temporally regulated through the …

FtsZ-Ring Regulation and Cell Division Are Mediated by Essential EzrA and Accessory Proteins ZapA and ZapJ in Streptococcus pneumoniae

AJ Perez, JB Villicana, HCT Tsui, ML Danforth… - Frontiers in …, 2021 - frontiersin.org
The bacterial FtsZ-ring initiates division by recruiting a large repertoire of proteins (the
divisome; Z-ring) needed for septation and separation of cells. Although FtsZ is essential …