Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

The heart is a unique organ in many ways. It consists of specialized muscle cells
(cardiomyocytes), which are adapted to contract constantly in a coordinated fashion. This is …

AS160 has emerged as a key player in insulin-mediated glucose transport through
controlling GLUT4 trafficking, which is thought to be regulated by insulin-stimulated …

Cardiomyocytes use glucose as well as fatty acids for ATP production. These substrates are
transported into the cell by glucose transporter 4 (GLUT4) and the fatty acid transporter …

The kinase Akt mediates signals from growth factor receptors for increased cell proliferation,
survival, and migration, which contribute to the positive effects of Akt in cancer progression …

Cell culture work suggests that signaling to polymerize cortical filamentous actin (F-actin)
represents a required pathway for the optimal redistribution of the insulin-responsive …

In order to investigate the importance of the PDK1–PKB–GSK3 signalling network in
regulating glycogen synthase (GS) in the heart, we have employed tissue specific …

There is clinical evidence to suggest that impaired myocardial glucose uptake contributes to
the pathogenesis of hypertrophic, insulin-resistant cardiomyopathy. The goal of this study …

Aims/hypothesis The present study was conducted to evaluate the effect of hyperglycaemia
in itself on glucose and lipid metabolism in human skeletal muscle cells. Methods Satellite …

A hypothesis that accounts for most of the available literature on insulin-stimulated GLUT4
translocation is that insulin action controls the access of GLUT4 vesicles to a constitutively …