Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases

AG Wu, XG Zhou, G Qiao, LU Yu, Y Tang, LU Yan… - Ageing research …, 2021 - Elsevier
Neuroinflammation is considered as a detrimental factor in neurodegenerative diseases,
including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) …

Oxidative stress in amyotrophic lateral sclerosis: pathophysiology and opportunities for pharmacological intervention

T Cunha-Oliveira, L Montezinho… - Oxidative medicine …, 2020 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease or Charcot
disease, is a fatal neurodegenerative disease that affects motor neurons (MNs) and leads to …

Neuroimmunology and neuroepigenetics in the establishment of sex differences in the brain

MM McCarthy, BM Nugent, KM Lenz - Nature Reviews Neuroscience, 2017 - nature.com
The study of sex differences in the brain is a topic of neuroscientific study that has broad
reaching implications for culture, society and biomedical science. Recent research in rodent …

Sex differences in neurodevelopmental and neurodegenerative disorders: focus on microglial function and neuroinflammation during development

R Hanamsagar, SD Bilbo - The Journal of steroid biochemistry and …, 2016 - Elsevier
Several neurological conditions are associated with sex differences in prevalence or
outcome. For example, autism predominantly affects boys, depression is more common in …

[PDF][PDF] Small-molecule modulation of TDP-43 recruitment to stress granules prevents persistent TDP-43 accumulation in ALS/FTD

MY Fang, S Markmiller, AQ Vu, A Javaherian… - Neuron, 2019 - cell.com
Stress granules (SGs) form during cellular stress and are implicated in neurodegenerative
diseases such as amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). To …

The role of sex and sex hormones in neurodegenerative diseases

E Vegeto, A Villa, S Della Torre, V Crippa… - Endocrine …, 2020 - academic.oup.com
Neurodegenerative diseases (NDs) are a wide class of disorders of the central nervous
system (CNS) with unknown etiology. Several factors were hypothesized to be involved in …

Identification of risk factors associated with onset and progression of amyotrophic lateral sclerosis using systematic review and meta-analysis

MD Wang, J Little, J Gomes, NR Cashman, D Krewski - Neurotoxicology, 2017 - Elsevier
Although amyotrophic lateral sclerosis (ALS) was identified as a neurological condition 150
years ago, risk factors related to the onset and progression of ALS remain largely unknown …

Sex: a significant risk factor for neurodevelopmental and neurodegenerative disorders

P Pinares-Garcia, M Stratikopoulos, A Zagato, H Loke… - Brain sciences, 2018 - mdpi.com
Males and females sometimes significantly differ in their propensity to develop neurological
disorders. Females suffer more from mood disorders such as depression and anxiety …

[PDF][PDF] Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation

H Shen, A Yanas, MC Owens, C Zhang, C Fritsch… - Molecular cell, 2022 - cell.com
Sex differences are pervasive in human health and disease. One major key to sex-biased
differences lies in the sex chromosomes. Although the functions of the X chromosome …

Neurotrophic and neuroregenerative effects of GH/IGF1

VE Bianchi, V Locatelli, L Rizzi - International journal of molecular …, 2017 - mdpi.com
Introduction. Human neurodegenerative diseases increase progressively with age and
present a high social and economic burden. Growth hormone (GH) and insulin-like growth …