Interindividual variability in genes encoding drug-metabolizing enzymes, transporters,
receptors, and human leukocyte antigens has a major impact on a patient's response to …

Drug discovery and development is a time-consuming process that involves identifying,
designing, and testing new drugs to address critical medical needs. In recent years, machine …

Recent advances in next-generation sequencing (NGS) have resulted in the identification of
tens of thousands of rare pharmacogenetic variations with unknown functional effects …

This paper aims to explore the possibility of employing large language models (LLMs)–a
type of artificial intelligence (AI)–in clinical pharmacology, with a focus on its possible …

This pilot study is aimed at implementing an approach for comprehensive clinical
pharmacogenomics (PGx) profiling. Fifty patients with cardiovascular diseases and 50 …

Fluoropyrimidines are chemotherapeutic agents widely used for the treatment of various
solid tumors. Commonly prescribed FPs include 5-fluorouracil (5-FU) and its oral prodrugs …

Background This pilot study aims to identify and functionally assess pharmacovariants in
whole exome sequencing data. While detection of known variants has benefited from …

Inter-individual variability in pharmacokinetics and drug response is heavily influenced by
single-nucleotide variants (SNVs) and copy-number variations (CNVs) in genes with …

Pharmacogenetics is a promising approach in future personalized medicine. This field holds
excellent prospects for healthcare quality acceleration. It promotes the transition to the …

Genetic factors have long been recognized as important determinants of interindividual
variability in drug efficacy and toxicity. However, despite the increasing number of …