Positron emission tomography (PET) constitutes a functional imaging technique that is
harnessed to probe biological processes in vivo. PET imaging has been used to diagnose …

Transition metal-mediated formation of C–N bonds is an essential synthetic methodology.
The discovery of the Chan–Lam amination provided a C–N bond forming process that was …

Peptides are a growing therapeutic class due to their unique spatial characteristics that can
target traditionally “undruggable” protein–protein interactions and surfaces. Despite their …

CuAAC chemistry is used to compose incredible synthetic molecular architectures and acts
as a true click chemistry reaction allowing densely functional molecular fragments to be …

Interrogating biological systems is often limited by access to biological probes. The
emergence of “click chemistry” has revolutionized bioconjugate chemistry by providing facile …

The advent of click chemistry has had a profound influence on almost all branches of
chemical science. This is particularly true of radiochemistry and the synthesis of agents for …

Bioorthogonal chemistry involves selective biocompatible reactions between functional
groups that are not normally present in biology. It has been used to probe biomolecules in …

Hydrogels are used in a wide variety of biomedical applications including tissue
engineering, biomolecule delivery, cell delivery, and cell culture. These hydrogels are often …

Click chemistry has been established rapidly as one of the most valuable methods for the
chemical transformation of complex molecules. Due to the rapid rates, clean conversions to …

The ability to selectively modify proteins at two or more defined locations opens new
avenues for manipulating, engineering, and studying living systems. As a chemical biology …