Targeting epigenetic regulators to overcome drug resistance in cancers
N Wang, T Ma, B Yu - Signal transduction and targeted therapy, 2023 - nature.com
Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic
regulation is a heritable change in gene expressions independent of nucleotide sequence …
regulation is a heritable change in gene expressions independent of nucleotide sequence …
JMJD family proteins in cancer and inflammation
W Manni, X Jianxin, H Weiqi, C Siyuan… - Signal transduction and …, 2022 - nature.com
The occurrence of cancer entails a series of genetic mutations that favor uncontrollable
tumor growth. It is believed that various factors collectively contribute to cancer, and there is …
tumor growth. It is believed that various factors collectively contribute to cancer, and there is …
Pharmacological inhibition of KDM5A for cancer treatment
Lysine-specific demethylase 5A (KDM5A, also named RBP2 or JARID1A) is a demethylase
that can remove methyl groups from histones H3K4me1/2/3. It is aberrantly expressed in …
that can remove methyl groups from histones H3K4me1/2/3. It is aberrantly expressed in …
Pirin is a prognostic marker of human melanoma that dampens the proliferation of malignant cells by downregulating JARID1B/KDM5B expression
C Penas, Y Arroyo-Berdugo, A Apraiz, J Rasero… - Scientific Reports, 2023 - nature.com
Originally considered to act as a transcriptional co-factor, Pirin has recently been reported to
play a role in tumorigenesis and the malignant progression of many tumors. Here, we have …
play a role in tumorigenesis and the malignant progression of many tumors. Here, we have …
A comparative view on molecular alterations and potential therapeutic strategies for canine oral melanoma
L Hardwick - Veterinary Sciences, 2021 - mdpi.com
Canine oral melanoma (COM) is a highly aggressive tumour associated with poor prognosis
due to metastasis and resistance to conventional anti-cancer therapies. As with human …
due to metastasis and resistance to conventional anti-cancer therapies. As with human …
Overcoming radio-resistance in esophageal squamous cell carcinoma via hypermethylation of PIK3C3 promoter region mediated by KDM5B loss
X Wang, M Gu, Y Ju, J Zhou - Journal of Radiation Research, 2022 - academic.oup.com
Many patients with esophageal squamous cell carcinoma (ESCC) are inoperable because
of old age or the advanced stage of the disease; thus radio-and chemotherapy are believed …
of old age or the advanced stage of the disease; thus radio-and chemotherapy are believed …