Studies of mammalian development have advanced our understanding of the genetic,
epigenetic, and cellular processes that orchestrate embryogenesis and have uncovered …

The placenta, being a temporary organ, plays a crucial role in facilitating the exchange of
nutrients and gases between the mother and the fetus during pregnancy. Any abnormalities …

The initiation of human pregnancy is marked by the implantation of an embryo into the
uterine environment; however, the underlying mechanisms remain largely elusive. To …

In contrast to rodents, the mechanisms underlying human trophectoderm and early placenta
specification are understudied due to ethical barriers and the scarcity of embryos. Recent …

It is now well-established that microRNAs (miRNAs) are important regulators of gene
expression. The role of miRNAs in placental development and trophoblast function is …

Background The placenta is essential for nutrient exchange and hormone production
between the mother and the developing fetus and serves as an invaluable model for …

Highlights•hTSCs can be derived from both primed and naive PSCs.•hTSC-state can be
induced from fibroblasts independently to pluripotency.•Stabilization of the naive TE state in …

Trophoblasts are specialized epithelial cells that perform critical functions during blastocyst
implantation and mediate maternal–fetal communication during pregnancy. However, our …

Understanding the molecular circuitries that govern early embryogenesis is important, yet
our knowledge of these in human preimplantation development remains limited. Small non …

Human trophoblast stem cells (hTSCs) can be derived from embryonic stem cells (hESCs) or
be induced from somatic cells by OCT4, SOX2, KLF4 and MYC (OSKM). Here we explore …