A roadmap to increase diversity in genomic studies
Two decades ago, the sequence of the first human genome was published. Since then,
advances in genome technologies have resulted in whole-genome sequencing and …
advances in genome technologies have resulted in whole-genome sequencing and …
Pan-genomics in the human genome era
RM Sherman, SL Salzberg - Nature Reviews Genetics, 2020 - nature.com
Since the early days of the genome era, the scientific community has relied on a single
'reference'genome for each species, which is used as the basis for a wide range of genetic …
'reference'genome for each species, which is used as the basis for a wide range of genetic …
High-depth African genomes inform human migration and health
The African continent is regarded as the cradle of modern humans and African genomes
contain more genetic variation than those from any other continent, yet only a fraction of the …
contain more genetic variation than those from any other continent, yet only a fraction of the …
Whole-genome sequencing reveals a complex African population demographic history and signatures of local adaptation
We conduct high coverage (> 30×) whole-genome sequencing of 180 individuals from 12
indigenous African populations. We identify millions of unreported variants, many predicted …
indigenous African populations. We identify millions of unreported variants, many predicted …
African genetic diversity and adaptation inform a precision medicine agenda
The deep evolutionary history of African populations, since the emergence of modern
humans more than 300,000 years ago, has resulted in high genetic diversity and …
humans more than 300,000 years ago, has resulted in high genetic diversity and …
Genetic substructure and complex demographic history of South African Bantu speakers
Abstract South Eastern Bantu-speaking (SEB) groups constitute more than 80% of the
population in South Africa. Despite clear linguistic and geographic diversity, the genetic …
population in South Africa. Despite clear linguistic and geographic diversity, the genetic …
A pan-African pathogen genomics data sharing platform to support disease outbreaks
A pan-African pathogen genomics data sharing platform to support disease outbreaks | Nature
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Medicine Skip to main content Thank you for visiting nature.com. You are using a browser …
Diversity in immunogenomics: the value and the challenge
Immunogenomics studies have been largely limited to individuals of European ancestry,
restricting the ability to identify variation in human adaptive immune responses across …
restricting the ability to identify variation in human adaptive immune responses across …
Tales of human migration, admixture, and selection in Africa
CM Schlebusch, M Jakobsson - Annual Review of Genomics …, 2018 - annualreviews.org
In the last three decades, genetic studies have played an increasingly important role in
exploring human history. They have helped to conclusively establish that anatomically …
exploring human history. They have helped to conclusively establish that anatomically …
Characterization of CYP2D6 Pharmacogenetic Variation in Sub‐Saharan African Populations
D Twesigomwe, BI Drögemöller… - Clinical …, 2023 - Wiley Online Library
Cytochrome P450 2D6 (CYP2D6) is a key enzyme in drug response owing to its
involvement in the metabolism of~ 25% of clinically prescribed medications. The encoding …
involvement in the metabolism of~ 25% of clinically prescribed medications. The encoding …