The filoviruses—Ebola virus and Marburg virus—cause lethal haemorrhagic fever in
humans and non-human primates (NHPs). Filoviruses present a global health threat both as …

To adequately prepare for potential hazards caused by emerging and reemerging infectious
diseases, the WHO has issued a list of high-priority pathogens that are likely to cause future …

Passive administration of monoclonal antibodies (mAbs) is a promising therapeutic
approach for Ebola virus disease (EVD). However, all mAbs and mAb cocktails that have …

Several ebolaviruses cause outbreaks of severe disease. Vaccines and monoclonal
antibody cocktails are available to treat Ebola virus (EBOV) infections, but not Sudan virus …

Recent and ongoing outbreaks of Ebola virus disease (EVD) underscore the unpredictable
nature of ebolavirus reemergence and the urgent need for antiviral treatments …

Due to its high mortality rate and continued re-emergence, Ebolavirus disease (EVD)
continues to pose a serious threat to global health. A group of viruses within the genus …

Small-animal models have been developed for several Filoviridae species; however, serial
adaptation was required to produce lethal infection. These adapted viruses have sequence …

Ebolaviruses cause severe disease in humans, and identification of monoclonal antibodies
(mAbs) that are effective against multiple ebolaviruses are important for therapeutics …

Previous efforts to identify cross-neutralizing antibodies to the receptor-binding site (RBS) of
ebolavirus glycoproteins have been unsuccessful, largely because the RBS is occluded on …

Viruses in the family Filoviridae, including the commonly known Ebola (EBOV) and Marburg
(MARV) viruses, can cause severe hemorrhagic fever in humans and nonhuman primates …