Research on astronaut health and model organisms have revealed six features of
spaceflight biology that guide our current understanding of fundamental molecular changes …

Human exploration of deep space will involve missions of substantial distance and duration.
To effectively mitigate health hazards, paradigm shifts in astronaut health systems are …

Spaceflight induces an immune response in astronauts. To better characterize this effect, we
generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data …

Abstract The SpaceX Inspiration4 mission provided a unique opportunity to study the impact
of spaceflight on the human body. Biospecimen samples were collected from four crew …

Abstract Space biology research aims to understand fundamental spaceflight effects on
organisms, develop foundational knowledge to support deep space exploration and …

Spaceflight and its associated stressors, such as microgravity, radiation exposure,
confinement, circadian derailment and disruptive workloads represent an unprecedented …

The harsh environmental conditions in space, particularly weightlessness and radiation
exposure, can negatively affect cardiovascular function and structure. In the future …

Widespread generation and analysis of omics data have revolutionized molecular medicine
on Earth, yet its power to yield new mechanistic insights and improve occupational health …

It is now widely recognised that the environment in space activates a diverse set of genes
involved in regulating fundamental cellular pathways. This includes the activation of genes …

Homo sapiens and their predecessors evolved in the context of the boundary conditions of
Earth, including a 1 g gravity and a geomagnetic field (GMF). These variables, plus others …