Bone is a dynamic tissue constantly responding to environmental changes such as
nutritional and mechanical stress. Bone homeostasis in adult life is maintained through bone …

Articular cartilage is commonly described as a tissue that is made of up to 80% water, is
devoid of blood vessels, nerves, and lymphatics, and is populated by only one cell type, the …

A fundamental question in bone biology concerns the contributions of skeletal
stem/progenitor cells (SSCs) in the bone marrow versus the periosteum to bone repair. We …

Large bone defects that cannot form a callus tissue are often faced with long-time recovery.
Developmental engineering-based strategies with mesenchymal stem cell (MSC) …

Bone consists of separate inner endosteal and outer periosteal compartments, each with
distinct contributions to bone physiology and each maintaining separate pools of cells owing …

Stem cell niches are specialized microenvironments that promote the maintenance of stem
cells and regulate their function. Recent advances have improved our understanding of the …

In mammals, hematopoietic stem cells (HSCs) engage in hematopoiesis throughout adult
life within the bone marrow, where they produce the mature cells necessary to maintain …

Skeletal stem cells regulate bone growth and homeostasis by generating diverse cell types,
including chondrocytes, osteoblasts and marrow stromal cells. The emerging concept …

Bone regeneration relies on the activation of skeletal stem cells (SSCs) that still remain
poorly characterized. Here, we show that periosteum contains SSCs with high bone …

Bone marrow mesenchymal lineage cells are a heterogeneous cell population involved in
bone homeostasis and diseases such as osteoporosis. While it is long postulated that they …