Revolutionizing our understanding of Parkinson's disease: Dr. Heinz Reichmann's pioneering research and future research direction
Millions of individuals around the world are afflicted with Parkinson's disease (PD), a
prevalent and incapacitating neurodegenerative disorder. Dr. Reichmann, a distinguished …
prevalent and incapacitating neurodegenerative disorder. Dr. Reichmann, a distinguished …
[HTML][HTML] Electrophilic metabolites targeting the KEAP1/NRF2 partnership
AT Dinkova-Kostova, H Hakomäki… - Current Opinion in …, 2024 - Elsevier
Numerous electrophilic metabolites are formed during cellular activity, particularly under
conditions of oxidative, inflammatory and metabolic stress. Among them are lipid oxidation …
conditions of oxidative, inflammatory and metabolic stress. Among them are lipid oxidation …
Orally delivered 2D covalent organic frameworks releasing kynurenine generate anti-inflammatory T cell responses in collagen induced arthritis mouse model
Covalent organic framework (COF) crystalline biomaterials have great potential for drug
delivery since they can load large amounts of small molecules (eg metabolites) and release …
delivery since they can load large amounts of small molecules (eg metabolites) and release …
[HTML][HTML] Nrf2 in TIME: the emerging role of nuclear factor erythroid 2-related factor 2 in the tumor immune microenvironment
J Feng, OJ Read, AT Dinkova-Kostova - Molecules and cells, 2023 - Elsevier
Nuclear factor erythroid 2-related factor 2 (Nrf2) mediates the cellular antioxidant response,
allowing adaptation and survival under conditions of oxidative, electrophilic and …
allowing adaptation and survival under conditions of oxidative, electrophilic and …
Extracellular Vesicle Size Reveals Cargo Specific to Coagulation and Inflammation in Pediatric and Adult Sickle Cell Disease
K Thangaraju, S Setua, C Lisk… - Clinical and Applied …, 2023 - journals.sagepub.com
Aberrant coagulation in sickle cell disease (SCD) is linked to extracellular vesicle (EV)
exposure. However, there is no consensus on the contributions of small EVs (SEVs) and …
exposure. However, there is no consensus on the contributions of small EVs (SEVs) and …
[HTML][HTML] Development of nitroalkene-based inhibitors to target STING-dependent inflammation
F Chang, C Gunderstofte, N Colussi, M Pitts… - Redox Biology, 2024 - Elsevier
Abstract Stimulator of Interferon Genes (STING) is essential for the inflammatory response to
cytosolic DNA. Despite that aberrant activation of STING is linked to an increasing number of …
cytosolic DNA. Despite that aberrant activation of STING is linked to an increasing number of …
N-formylkynurenine but not kynurenine enters a nucleophile-scavenging branch of the immune-regulatory kynurenine pathway
Tryptophan catabolism along the kynurenine pathway (KP) mediates key physiological
functions ranging from immune tolerance to lens UV protection, but the contributory roles …
functions ranging from immune tolerance to lens UV protection, but the contributory roles …
A novel 1-benzoazepine-derived Michael acceptor and its hetero-adducts active against MRSA
O Caletková, L Pinčeková, J Nováčiková… - Organic & …, 2024 - pubs.rsc.org
Multidrug-resistant bacterial infections continue to be a rising global health concern. Herein,
we describe the development of a novel class of 3-substituted benzoazepinedione …
we describe the development of a novel class of 3-substituted benzoazepinedione …
[HTML][HTML] The chemical biology of dinitrogen trioxide
MN Möller, DA Vitturi - Redox Biochemistry and Chemistry, 2024 - Elsevier
Abstract Dinitrogen trioxide (N 2 O 3) mediates low-molecular weight and protein S-and N-
nitrosation, with recent reports suggesting a role in the formation of nitrating intermediates as …
nitrosation, with recent reports suggesting a role in the formation of nitrating intermediates as …