Whole genome sequencing (WGS) of Mycobacterium tuberculosis has rapidly progressed
from a research tool to a clinical application for the diagnosis and management of …

Tuberculosis (TB) is a global infectious threat that is intensified by an increasing incidence of
highly drug-resistant disease. Whole-genome sequencing (WGS) studies of Mycobacterium …

Background Tuberculosis, caused by bacteria in the Mycobacterium tuberculosis complex
(MTBC), is a major global public health burden. Strain-specific genomic diversity in the …

Background Tracking recent transmission is a vital part of controlling widespread pathogens
such as Mycobacterium tuberculosis. Multiple methods with specific performance …

Due to its rapid spread and association with the numerous outbreaks, the global spread of
East Asian lineage of Mycobacterium tuberculosis strains presents a global concern …

The PE and PPE proteins of Mycobacterium tuberculosis have been studied with great
interest since their discovery. Named after the conserved proline (P) and glutamic acid (E) …

Although recombination is accepted to be common in bacteria, for many species robust
phylogenies with well-resolved branches can be reconstructed from whole genome …

Recent advances in bacterial whole-genome sequencing have resulted in a comprehensive
catalog of antibiotic resistance genomic signatures in Mycobacterium tuberculosis. With a …

The genome of Mycobacterium tuberculosis, the bacterium responsible for the disease
tuberculosis, contains an unusual family of abundant antigens (PE/PPEs). To date, certain …

First achieved in 1998 by Cole et al., the complete genome sequence of Mycobacterium
tuberculosis continues to provide an invaluable resource to understand tuberculosis (TB) …