Importance Sickle cell disease (SCD) is an inherited disorder of hemoglobin, characterized
by formation of long chains of hemoglobin when deoxygenated within capillary beds …

Avascular necrosis (AVN) of the femoral head is caused by disruption of the blood supply to
the proximal femur. The alterations in the blood supply may occur following a traumatic …

Due to improvements in treatment and care, the life expectancy of patients with sickle cell
disease (SCD) has improved over the last 50 years1 such that many patients now survive to …

Sickle cell disease and its variants constitute the most common inherited blood disorders
affecting millions of individuals worldwide. Significant information regarding the nature of the …

Osteonecrosis of the femoral head (ONFH) is a debilitating disease with major social and
economic impacts. It frequently affects relatively young adults and has a predilection for …

Objectives: Identify the epidemiology of femoral head avascular necrosis. Describe the
evaluation of femoral head avascular necrosis. Summarize the treatment options available …

Sickle cell disease (SCD) is an autosomal recessive genetic condition that alters the shape
and function of the hemoglobin molecule in red blood cells. While the overall survival rate …

Osteonecrosis, a form of ischemic bone injury that leads to degenerative joint disease,
affects∼ 30% of people with sickle cell disease. Although osteonecrosis most commonly …

Adverse pregnancy outcomes occur frequently in women with sickle cell disease (SCD)
across the globe. In the United States, Black women experience disproportionately worse …

Background Transition from pediatric to adult care is a period of high risk for loss to follow‐
up, morbidity, and mortality in adolescents and young adults (AYA) with …