The survival of vertebrate organisms depends on highly regulated delivery of oxygen and
nutrients through vascular networks that pervade nearly all tissues in the body …

Fibrosis is defined as the excessive deposition of extracellular matrix (ECM) proteins in the
interstitium. It is an essential pathological response to chronic inflammation. ECM protein …

Blood and lymphatic vessels form a versatile transport network and provide inductive signals
to regulate tissue-specific functions. Blood vessels in bone regulate osteogenesis and …

Barrier epithelia depend upon resident stem cells for homeostasis, defense, and repair.
Epithelial stem cells of small and large intestines (ISCs) respond to their local …

Lgr5+ intestinal stem cells (ISCs) depend on niche factors for their proper function. However,
the source of these ISC niche factors and how they support ISCs in vivo remain …

Disruption of lymphatic lipid transport is linked to obesity and type 2 diabetes (T2D), but
regulation of lymphatic vessel function and its link to disease remain unclear. Here we show …

The epithelial tissues that line our body, such as the skin and gut, have remarkable
regenerative prowess and continually renew throughout our lifetimes. Owing to their barrier …

Heart regenerative medicine has been gradually evolving from a view of the heart as a
nonregenerative organ with terminally differentiated cardiac muscle cells. Understanding the …

BACKGROUND: The adult mammalian heart is incapable of regeneration, whereas a
transient regenerative capacity is maintained in the neonatal heart, primarily through the …

The intestinal vasculature has been studied for the last 100 years, and its essential role in
absorbing and distributing ingested nutrients is well known. Recently, fascinating new …