Background Chronic pain is frequently comorbid with depression in clinical practice.
Recently, alterations in gut microbiota and metabolites derived therefrom have been found …

The present communication offers a comprehensive overview of the self-assembly of bile
salts emphasizing their mixed smart aggregates with a variety of amphiphiles. Using an …

Bile acids are naturally produced in humans and are known to provide human health
benefits through their endocrinological, microfloral, metabolic and other åffects that are still …

Long-term stress causes hyperalgesia; and there are gender differences in the mechanism
of pain in male and female individuals. The role of gut microbiota in pain has also been …

Bile acids are a special group of biological surfactants which can express different
physiological and pharmacological effects. Micellar solutions of bile acids can solubilizate …

Objective The anticancer efficacy of orally administered chemotherapeutics is often
constrained by low intestinal membrane permeability and oral bioavailability. In this context …

Abdominal pain in patients with inflammatory bowel diseases (IBDs) is very common and up
to 80% of patients experience some type of acute pain as a result of inflammation and/or …

The objective of this work was to study the effect of structure of bile acids on their
membranolytic potential and extent of overlapping of the information about the …

The objective of this study was to understand the prolonged analgesic action of morphine
hydrochloride observed in the presence of sodium 12-oxochenodeoxycholanate. Based on …

Critical micellear concentrations (CMC) were determined for two novel promoters of
membrane permeability—7-monoketocholic acid (7-MKC) and 12-monoketocholic acid (12 …