Patients with isolated rapid-eye-movement sleep behaviour disorder (RBD) are commonly
regarded as being in the early stages of a progressive neurodegenerative disease involving …

Many of the motor symptoms of Parkinson disease (PD) can be preceded, sometimes for
several years, by non-motor symptoms that include hyposmia, sleep disorders, depression …

Parkinson's disease (PD) may start in the gut and spread to the brain. To investigate the role
of gut microbiome, we conducted a large-scale study, at high taxonomic resolution, using …

Idiopathic REM sleep behaviour disorder (iRBD) is a powerful early sign of Parkinson's
disease, dementia with Lewy bodies, and multiple system atrophy. This provides an …

The genetic landscape of Parkinson's disease (PD) is characterised by rare high penetrance
pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a …

Rapid eye movement (REM) sleep behaviour disorder (RBD) is a parasomnia that is
characterized by loss of muscle atonia during REM sleep (known as REM sleep without …

Several studies have confirmed the α-synuclein real-time quaking-induced conversion (RT-
QuIC) assay to have high sensitivity and specificity for Parkinson's disease. However …

Parkinson's disease has a long prodromal stage with various subclinical motor and non-
motor manifestations; however, their evolution in the years before Parkinson's disease is …

So-called idiopathic rapid eye movement (REM) sleep behaviour disorder (RBD), formerly
seen as a rare parasomnia, is now recognized as the prodromal stage of an α …

This article describes research criteria and probability methodology for the diagnosis of
prodromal PD. Prodromal disease refers to the stage wherein early symptoms or signs of PD …