Iron: protector or risk factor for cardiovascular disease? Still controversial

C Muñoz-Bravo, M Gutiérrez-Bedmar… - Nutrients, 2013 - mdpi.com
Iron is the second most abundant metal in the Earth's crust. Despite being present in trace
amounts, it is an essential trace element for the human body, although it can also be toxic …

Iron-induced fibrin in cardiovascular disease

B Lipinski, E Pretorius - Current neurovascular research, 2013 - ingentaconnect.com
Accumulating evidence within the last two decades indicates the association between
cardiovascular disease (CVD) and chronic inflammatory state. Under normal conditions …

Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia

I Cortés-Puch, D Wang, J Sun… - Blood, The Journal …, 2014 - ashpublications.org
In a randomized controlled blinded trial, 2-year-old purpose-bred beagles (n= 24), with
Staphylococcus aureus pneumonia, were exchanged-transfused with either 7-or 42-day-old …

High ferritin levels have major effects on the morphology of erythrocytes in Alzheimer's disease

J Bester, AV Buys, B Lipinski, DB Kell… - Frontiers in aging …, 2013 - frontiersin.org
Introduction: Unliganded iron both contributes to the pathology of Alzheimer's disease (AD)
and also changes the morphology of erythrocytes (RBCs). We tested the hypothesis that …

Profound morphological changes in the erythrocytes and fibrin networks of patients with hemochromatosis or with hyperferritinemia, and their normalization by iron …

E Pretorius, J Bester, N Vermeulen, B Lipinski… - PloS one, 2014 - journals.plos.org
It is well-known that individuals with increased iron levels are more prone to thrombotic
diseases, mainly due to the presence of unliganded iron, and thereby the increased …

Dietary lactoferrin alleviates age-related lacrimal gland dysfunction in mice

M Kawashima, T Kawakita, T Inaba, N Okada, M Ito… - PLoS …, 2012 - journals.plos.org
Background Decrease in lacrimal gland secretory function is related to age-induced dry eye
disease. Lactoferrin, the main glycoprotein component of tears, has multiple functions …

The case for an estrogen-iron axis in health and disease

M Hamad, K Bajbouj, J Taneera - Experimental and Clinical …, 2020 - thieme-connect.com
Clinical and experimental evidence suggest that estrogen manipulates intracellular iron
metabolism and that elevated levels of estrogen associate with increased systemic iron …

The role of iron-induced fibrin in the pathogenesis of Alzheimer's disease and the protective role of magnesium

B Lipinski, E Pretorius - Frontiers in human neuroscience, 2013 - frontiersin.org
Amyloid hypothesis of Alzheimer's disease (AD) has recently been challenged by the
increasing evidence for the role of vascular and hemostatic components that impair oxygen …

Deranged iron status in psoriasis: the impact of low body mass

M Ponikowska, M Tupikowska… - Journal of cachexia …, 2015 - Wiley Online Library
Background Iron deficiency (ID) frequently complicates inflammatory‐mediated chronic
disorders, irrespective of anaemia. Psoriasis is a chronic, immune‐mediated skin disease …

Serum ferritin levels and the development of metabolic syndrome and its components: a 6.5-year follow-up study

P Hämäläinen, J Saltevo, H Kautiainen… - Diabetology & metabolic …, 2014 - Springer
Background The aim of this study was to investigate the relationship between changes in
serum ferritin concentrations and the development of metabolic syndrome (MetS) and its …