The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the
risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly …

Obesity usually is accompanied by inflammation of fat tissue, with a prominent role of
visceral fat. Chronic inflammation in obese fat tissue is of a lower grade than acute immune …

The landmark discoveries of leptin and adiponectin firmly established adipose tissue as a
sophisticated and highly active endocrine organ, opening a new era of investigating adipose …

Alongside the liver, white adipose tissue (WAT) is critical in regulating systemic energy
homeostasis. Although each organ has its specialised functions, they must work …

Obesity is the most common cause of insulin resistance, and the current obesity epidemic is
driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic …

Abstract Obesity contributes 65–75% of the risk for human primary (essential) hypertension
(HT) which is a major driver of cardiovascular and kidney diseases. Kidney dysfunction …

Obesity is accompanied by numerous systemic and tissue-specific derangements, including
systemic inflammation, insulin resistance, and mitochondrial abnormalities in skeletal …

Iron is essential to many fundamental biological processes, but its cellular
compartmentalization and concentration must be tightly controlled. Although iron overload …

The study of adipose tissue (AT) is enjoying a renaissance. White, brown, and beige
adipocytes are being investigated in adult animals, and the critical roles of small depots like …

Adipose, or fat, tissue (AT) was once considered an inert tissue that primarily existed to store
lipids, and was not historically recognized as an important organ in the regulation and …