Thyroid hormone is essential for fetal (brain) development. Plasma membrane transporters
control the intracellular bioavailability of thyroid hormone. In the past few decades, 15 …

Introduction The treatment of neurological diseases is significantly hampered by the lack of
available therapeutics. A major restraint for the development of drugs is denoted by the …

Delivering genes to and across the brain vasculature efficiently and specifically across
species remains a critical challenge for addressing neurological diseases. We have evolved …

Blood-brain barrier (BBB) breakdown and immune cell infiltration into the central nervous
system (CNS) are early hallmarks of multiple sclerosis (MS). High numbers of CD8+ T cells …

Neural stem cells in the murine subventricular zone (SVZ) reactivate during postnatal
development to generate neurons and glia throughout adulthood. We previously …

Dysfunctions of the thyroid hormone (TH) transporting monocarboxylate transporter MCT8
lead to a complex X-linked syndrome with abnormal serum TH concentrations and …

Treating central nervous system (CNS) diseases is complicated by the incapability of
numerous therapeutics to cross the blood–brain barrier (BBB), mainly composed of brain …

Inactivating mutations in the specific thyroid hormone transporter monocarboxylate
transporter 8 (MCT8) lead to an X-linked rare disease named MCT8 deficiency or Allan …

Introduction The SCL16A2 gene encodes the thyroid hormone (TH) transporter MCT8.
Pathogenic variants result in a reduced TH uptake into the CNS despite high serum T3 …

Monocarboxylate transporter 8 (MCT8) deficiency is a rare, X-linked disorder arising from
mutations in the SLC16A2 gene and resulting from dysfunctional thyroid hormone transport …