Highlights•Dementia involves the chronic and progressive deterioration of cognitive
functions.•Alzheimer's disease is the most common form of dementia.•Abnormally …

Metformin has been used for ages to treat diabetes mellitus due to its safety profile and low
cost. However, metformin has variable pharmacokinetics in patients, and due to its poor oral …

Tau and α-synuclein (α-syn) are prone-to-aggregate proteins that can be responsible for
pathological lesions found in the brains of Alzheimer's disease (AD), Lewy body dementia …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder underlying
dementia in the geriatric population. AD manifests by two pathological hallmarks …

Alzheimer's disease (AD) and Parkinson's disease (PD) are multifactorial, chronic diseases
involving neurodegeneration. According to recent studies, it is hypothesized that the …

Tau and α-synuclein aggregates are the main histopathological hallmarks present in
Alzheimer's disease (AD), Parkinson's disease (PD), and other neurodegenerative …

Alzheimer's disease (AD) is a multifactorial, chronic neurodegenerative disease
characterized by the presence of extracellular β-amyloid (Aβ) plaques, intraneuronal …

Parkinson's disease (PD) is the second most common neurodegenerative disease, affecting
the elderly population worldwide. In PD, the misfolding of α-synuclein (α-syn) results in the …

Facile synthetic procedures and broad spectrum of biological activities are special attributes
of sulfonamides. Sulfonamide derivatives have demonstrated potential as a class of …

My research projects focuses on the dual targeting of small molecules to abrogate aberrant
α-syn, tau (2N4R), and p-tau (1N4R) aggregation and to reduce the spread of AD and …