Decades of research have identified genetic factors and biochemical pathways involved in
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …

Ageing is an inevitable event in the lifecycle of all organisms, characterized by progressive
physiological deterioration and increased vulnerability to death. Ageing has also been …

Synucleinopathies are characterized by the accumulation of α-synuclein (α-Syn) aggregates
in the brain. Positron emission tomography (PET) imaging of synucleinopathies requires …

Abstract α-Synuclein (α-syn) amyloid fibrils are the major component of Lewy bodies, which
are the pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. High …

Misfolded protein aggregates represent a continuum with overlapping features in
neurodegenerative diseases, but differences in protein components and affected brain …

The classic view portrays Parkinson disease (PD) as a motor disorder resulting from loss of
substantia nigra pars compacta dopaminergic neurons. Multiple studies, however, describe …

The defining features of Alzheimer disease (AD) include conspicuous changes in both brain
histology and behavior. The AD brain is characterized microscopically by the combined …

A relatively small number of especially susceptible nerve cell types within multiple
neurotransmitter systems of the human central, peripheral, and enteric nervous systems …

The collapse of neural networks important for memory and cognition, including death of
neurons and degeneration of synapses, causes the debilitating dementia associated with …

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