There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …

Atrial fibrillation (AF) is an extremely prevalent arrhythmia that presents a wide range of
therapeutic challenges. AF usually begins in a self-terminating paroxysmal form (pAF). With …

Crucial conventional patch-clamp approaches to investigate cellular electrophysiology suffer
from low-throughput and require considerable experimenter expertise. Automated patch …

Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with
pronounced morbidity and mortality. Its prevalence, expected to further increase for the …

Rationale: Junctional membrane complexes (JMCs) in myocytes are critical microdomains,
in which excitation–contraction coupling occurs. Structural and functional disruption of JMCs …

Atrial fibrillation (AF) is the most common form of cardiac arrhythmia and significantly
increases the risks of morbidity, mortality and health care expenditure; however, treatment …

ABSTRACT Introduction: Type-2 ryanodine receptor (RyR2) located on the sarcoplasmic
reticulum initiate systolic Ca2+ transients within cardiomyocytes. Proper functioning of RyR2 …

Arrhythmias are a class of cardiac dysfunction characterized by heart rate disturbances and
heart rhythm abnormalities, which are associated with substantial morbidity and mortality …

Background: Atrial fibrillation (AF), the most common arrhythmia, is associated with the
downregulation of FKBP5 (encoding FKBP5 [FK506 binding protein 5]). However, the …

Objective: This study aimed to evaluate the protective effects of atorvastatin against
myocardial ischemia/reperfusion (I/R) injury in cardiomyocytes and its possible underlying …