Calcium signaling and cardiac arrhythmias
There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …
Electrophysiological and molecular mechanisms of paroxysmal atrial fibrillation
Atrial fibrillation (AF) is an extremely prevalent arrhythmia that presents a wide range of
therapeutic challenges. AF usually begins in a self-terminating paroxysmal form (pAF). With …
therapeutic challenges. AF usually begins in a self-terminating paroxysmal form (pAF). With …
A modern automated patch-clamp approach for high throughput electrophysiology recordings in native cardiomyocytes
F Seibertz, M Rapedius, FE Fakuade, P Tomsits… - Communications …, 2022 - nature.com
Crucial conventional patch-clamp approaches to investigate cellular electrophysiology suffer
from low-throughput and require considerable experimenter expertise. Automated patch …
from low-throughput and require considerable experimenter expertise. Automated patch …
MicroRNAs in atrial fibrillation: from expression signatures to functional implications
NWE van den Berg, M Kawasaki, WR Berger… - … Drugs and Therapy, 2017 - Springer
Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with
pronounced morbidity and mortality. Its prevalence, expected to further increase for the …
pronounced morbidity and mortality. Its prevalence, expected to further increase for the …
SPEG (striated muscle preferentially expressed protein kinase) is essential for cardiac function by regulating junctional membrane complex activity
AP Quick, Q Wang, LE Philippen… - Circulation …, 2017 - Am Heart Assoc
Rationale: Junctional membrane complexes (JMCs) in myocytes are critical microdomains,
in which excitation–contraction coupling occurs. Structural and functional disruption of JMCs …
in which excitation–contraction coupling occurs. Structural and functional disruption of JMCs …
[HTML][HTML] Weighted gene co‑expression network analysis to identify key modules and hub genes associated with atrial fibrillation
W Li, L Wang, Y Wu, Z Yuan… - … Journal of Molecular …, 2020 - spandidos-publications.com
Atrial fibrillation (AF) is the most common form of cardiac arrhythmia and significantly
increases the risks of morbidity, mortality and health care expenditure; however, treatment …
increases the risks of morbidity, mortality and health care expenditure; however, treatment …
Targeting pathological leak of ryanodine receptors: preclinical progress and the potential impact on treatments for cardiac arrhythmias and heart failure
P Connell, TA Word, XHT Wehrens - Expert opinion on therapeutic …, 2020 - Taylor & Francis
ABSTRACT Introduction: Type-2 ryanodine receptor (RyR2) located on the sarcoplasmic
reticulum initiate systolic Ca2+ transients within cardiomyocytes. Proper functioning of RyR2 …
reticulum initiate systolic Ca2+ transients within cardiomyocytes. Proper functioning of RyR2 …
Non-coding RNA and arrhythmias: expression, function, and molecular mechanism
Y Zeng, N Wu, Z Zhang, L Zhong, G Li, Y Li - Europace, 2023 - academic.oup.com
Arrhythmias are a class of cardiac dysfunction characterized by heart rate disturbances and
heart rhythm abnormalities, which are associated with substantial morbidity and mortality …
heart rhythm abnormalities, which are associated with substantial morbidity and mortality …
Downregulation of FKBP5 promotes atrial arrhythmogenesis
Background: Atrial fibrillation (AF), the most common arrhythmia, is associated with the
downregulation of FKBP5 (encoding FKBP5 [FK506 binding protein 5]). However, the …
downregulation of FKBP5 (encoding FKBP5 [FK506 binding protein 5]). However, the …
[HTML][HTML] Atorvastatin protects myocardium against ischemia-reperfusion injury through inhibiting miR-199a-5p
YB Zuo, YZ Wang, HJ Hu, W Cui - Cellular Physiology and Biochemistry, 2016 - karger.com
Objective: This study aimed to evaluate the protective effects of atorvastatin against
myocardial ischemia/reperfusion (I/R) injury in cardiomyocytes and its possible underlying …
myocardial ischemia/reperfusion (I/R) injury in cardiomyocytes and its possible underlying …