The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …

Genetically encoded fluorescent biosensors have revolutionized the study of cell signaling
and metabolism, as they allow for live-cell measurements with high spatiotemporal …

AMP-activated protein kinase (AMPK) is a master regulator of cellular energetics which
coordinates metabolism by phosphorylating a plethora of substrates throughout the cell. But …

Mitochondria are widely considered the “power hub” of the cell because of their pivotal roles
in energy metabolism and oxidative phosphorylation. However, beyond the production of …

The objective of this study was to investigate the effects of dietary intervention on intestinal
microbiota-mediated change in short chain fatty acid (SCFA) profile and intestinal …

Rotenone is a widely used organic pesticide; its serious side effect for off‐target species is
neurotoxicity. The primary mechanism of rotenone toxicity is inhibition of the mitochondrial …

Cardiotoxicity is a critical concern in the use of several cytotoxic drugs. Induction of
apoptosis, inflammation, and autophagy following dysregulation of the PI3K/Akt signaling …

Background Myocardial necrosis caused by myocardial ischemia-reperfusion (MI/R) in
diabetic patients is prominently aggravated and can cause oxidative stress. Nuclear factor …

Abstract F 1 FO ATP synthase, also known as complex V, is a key enzyme of mitochondrial
energy metabolism that can synthesize and hydrolyze ATP. It is not known whether the ATP …

Inflammation is an adaptive response to tissue injury, which is a critical process in order to
restore tissue functionality and homeostasis. The association between inflammation and …