Non-alkaloid cholinesterase inhibitory compounds from natural sources
Alzheimer's disease (AD) is a severe neurodegenerative disorder of different brain regions
accompanied by distresses and affecting more than 25 million people in the world. This …
accompanied by distresses and affecting more than 25 million people in the world. This …
Gartanin as an Isoprenylated Xanthone from Mangosteen (Garcinia mangostana L.): Insights into Its Synthesis, Extraction, Determination, and Bioactivity
Q Zhang, L Wang, H Li, F Wu, Z Tang, H Li… - Food Reviews …, 2024 - Taylor & Francis
ABSTRACT Gartanin, a 4-prenylated xanthone, is a bioactive secondary metabolite found in
mangosteen. In contrast to mangostins, another class of xanthone derivatives in …
mangosteen. In contrast to mangostins, another class of xanthone derivatives in …
Phytochemical composition, antimicrobial activities, and cholinesterase inhibitory properties of the lichen Usnea diffracta Vain
YM Hao, YC Yan, Q Zhang, BQ Liu, CS Wu… - Frontiers in …, 2023 - frontiersin.org
Lichens are important sources of versatile bioactive compounds. Two new dibenzofurans (1–
2), a multi-substituted single benzene ring (3), and two organic acid compounds (4–5) along …
2), a multi-substituted single benzene ring (3), and two organic acid compounds (4–5) along …
Moringa oleifera Lam. leaf extract safely inhibits periodontitis by regulating the expression of p38α/MAPK14-OPG/RANKL
F Wang, S Long, J Zhang - Archives of Oral Biology, 2021 - Elsevier
Periodontitis is a chronic disease clinically defined by loss of alveolar bone and connective
tissue degeneration. Although Moringa oleifera Lam.(MO), a tree belonging to the …
tissue degeneration. Although Moringa oleifera Lam.(MO), a tree belonging to the …
Garcinoxanthones SV, new xanthone derivatives from the pericarps of Garcinia mangostana together with their cytotoxic and antioxidant activities
Abstract Xanthones (9H-xanthene-9-ones) are considered to be very promising compounds
due to a variety of interesting biological and pharmacological activities. In this study, column …
due to a variety of interesting biological and pharmacological activities. In this study, column …
Volatile and phenolic profiling of a traditional medicinal plant, Hypericum empetrifolium with in vitro biological activities
Abstract Ethnopharmacological relevance Hypericum empetrifolium Willd is a member of the
Hypericaceae family, mainly known in southern Greece, and western Turkey. Being a …
Hypericaceae family, mainly known in southern Greece, and western Turkey. Being a …
New 3-O-substituted xanthone derivatives as promising acetylcholinesterase inhibitors
A new series of 3-O-substituted xanthone derivatives were synthesised and evaluated for
their anti-cholinergic activities against acetylcholinesterase (AChE) and …
their anti-cholinergic activities against acetylcholinesterase (AChE) and …
Secondary metabolites from the barks of Garcinia griffithii T. anderson (Clusiaceae) and their chemophenetic significance
A total of thirteen compounds consisting of nine xanthones; cowagarcinone C (1),
doitunggarcinone C (2), nigrolineaxanthone E (3), nigrolineaxanthone Q (4), β-mangostin …
doitunggarcinone C (2), nigrolineaxanthone E (3), nigrolineaxanthone Q (4), β-mangostin …
Inhibition of Acetylcholinesterase by Novel Lupinine Derivatives
IA Schepetkin, ZS Nurmaganbetov, SD Fazylov… - Molecules, 2023 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
memory loss and cognitive impairment due in part to a severe loss of cholinergic neurons in …
memory loss and cognitive impairment due in part to a severe loss of cholinergic neurons in …
Synthesis of 1-hydroxy-3-O-substituted xanthone derivatives and their structure-activity relationship on acetylcholinesterase inhibitory effect
This study focused on the synthesis of 1, 3-dihydroxyxanthone (1) and its new derivatives
with alkyl (2a–2f), alkenyl (2 g–2k), alkynyl (2 l–2n), and alkylated phenyl (2o–2r) groups at …
with alkyl (2a–2f), alkenyl (2 g–2k), alkynyl (2 l–2n), and alkylated phenyl (2o–2r) groups at …