Alzheimer's disease (AD) is the foremost type of dementia that afflicts considerable morbidity
and mortality in aged population. Several transcription molecules, pathways, and molecular …

The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

Protein-tyrosine kinases (PTKs) are important regulators of intracellular signal-transduction
pathways mediating development and multicellular communication in metazoans. Their …

(Hunter, 1998). RTKs play an important role in the control 1998; Jiang and Hunter, 1999).
Receptor dimerization is of most fundamental cellular processes including the further …

Recent research has examined Akt and Akt-related serine–threonine kinases in signaling
cascades that regulate cell survival and are important in the pathogenesis of degenerative …

Introduction 3. Reactive oxygen species in tumor growth and cellular survival 4. Reactive
oxygen species in cell motility and metastasis formation 5. Generation of reactive oxygen …

▪ Abstract The p21-activated kinases (PAKs) 1–3 are serine/threonine protein kinases whose
activity is stimulated by the binding of active Rac and Cdc42 GTPases. Our understanding of …

The Akt serine/threonine kinase (also called protein kinase B) has emerged as a critical
signaling molecule within eukaryotic cells. Significant progress has been made in clarifying …

The Hippo signaling pathway inhibits cell growth and regulates organ size through a kinase
cascade that leads to the phosphorylation and nuclear exclusion of the growth-promoting …

The serine/threonine protein kinase PKB (also known as Akt) is thought to be a key mediator
of signal transduction processes. The identification of PKB substrates and the role PKB …