Importance Malignant primary brain tumors cause more than 15 000 deaths per year in the
United States. The annual incidence of primary malignant brain tumors is approximately 7 …

In response to major changes in diagnostic algorithms and the publication of mature results
from various large clinical trials, the European Association of Neuro-Oncology (EANO) …

Background Isocitrate dehydrogenase (IDH)–mutant grade 2 gliomas are malignant brain
tumors that cause considerable disability and premature death. Vorasidenib, an oral brain …

Background Detection of the BRAF V600E mutation in pediatric low-grade glioma has been
associated with a lower response to standard chemotherapy. In previous trials, dabrafenib …

Glioblastomas are the most common form of malignant primary brain tumor and an important
cause of morbidity and mortality. In recent years there have been important advances in …

Glioblastoma is the most common primary malignant brain tumor in adults and is associated
with poor survival. The Ivy Foundation Early Phase Clinical Trials Consortium conducted a …

The most frequent adult-type primary CNS tumours are diffuse gliomas, but a large variety of
rarer CNS tumour types exists. The classification of these tumours is increasingly based on …

Gliomas are the most common primary brain malignancies, with different degrees of
aggressiveness, variable prognosis and various heterogeneous histologic sub-regions, ie …

Judgement, as one of the core tenets of medicine, relies upon the integration of multilayered
data with nuanced decision making. Cancer offers a unique context for medical decisions …

Background Bevacizumab is approved for the treatment of patients with progressive
glioblastoma on the basis of uncontrolled data. Data from a phase 2 trial suggested that the …