Colorectal cancer risk assessment and precision approaches to screening: brave new world or worlds apart?
Current colorectal cancer (CRC) screening recommendations take a “one-size-fits-all”
approach using age as the major criterion to initiate screening. Precision screening that …
approach using age as the major criterion to initiate screening. Precision screening that …
Effectiveness of colorectal cancer (CRC) screening on all-cause and CRC-specific mortality reduction: a systematic review and meta-analysis
Simple Summary Colorectal cancer (CRC) screening is one of the most effective measures
to prevent CRC resulting in a decrease in CRC mortality. Mortality reduction (MR) from CRC …
to prevent CRC resulting in a decrease in CRC mortality. Mortality reduction (MR) from CRC …
Risk stratification for early-onset colorectal cancer using a combination of genetic and environmental risk scores: an international multi-center study
Background The incidence of colorectal cancer (CRC) among individuals aged younger
than 50 years has been increasing. As screening guidelines lower the recommended age of …
than 50 years has been increasing. As screening guidelines lower the recommended age of …
The emerging field of polygenic risk scores and perspective for use in clinical care
Genetic testing is used widely for diagnostic, carrier and predictive testing in monogenic
diseases. Until recently, there were no genetic testing options available for multifactorial …
diseases. Until recently, there were no genetic testing options available for multifactorial …
[HTML][HTML] Can polygenic risk scores contribute to cost-effective cancer screening? A systematic review
Purpose Polygenic risk influences susceptibility to cancer. We assessed whether polygenic
risk scores could be used in conjunction with other predictors of future disease status in cost …
risk scores could be used in conjunction with other predictors of future disease status in cost …
Polygenic risk prediction models for colorectal cancer: a systematic review
M Sassano, M Mariani, G Quaranta, R Pastorino… - BMC cancer, 2022 - Springer
Background Risk prediction models incorporating single nucleotide polymorphisms (SNPs)
could lead to individualized prevention of colorectal cancer (CRC). However, the added …
could lead to individualized prevention of colorectal cancer (CRC). However, the added …
Risk‐stratified strategies in population screening for colorectal cancer
I Lansdorp‐Vogelaar, R Meester… - … Journal of Cancer, 2022 - Wiley Online Library
Colorectal cancer (CRC) screening has been demonstrated to reduce CRC incidence and
mortality. However, besides such benefits, CRC screening is also associated with potential …
mortality. However, besides such benefits, CRC screening is also associated with potential …
[HTML][HTML] Colorectal cancer screening in China: status, challenges, and prospects—China, 2022
Colorectal cancer (CRC) ranks third among the most commonly diagnosed cancers in
China. Despite proof that screening can decrease CRC incidence and mortality, there are …
China. Despite proof that screening can decrease CRC incidence and mortality, there are …
The costs and benefits of risk stratification for colorectal cancer screening based on phenotypic and genetic risk: a health economic analysis
C Thomas, O Mandrik, CL Saunders… - Cancer Prevention …, 2021 - AACR
Population-based screening for colorectal cancer is an effective and cost-effective way of
reducing colorectal cancer incidence and mortality. Many genetic and phenotypic risk factors …
reducing colorectal cancer incidence and mortality. Many genetic and phenotypic risk factors …
Risk assessment for hip and knee osteoarthritis using polygenic risk scores
B Sedaghati‐Khayat, CG Boer, J Runhaar… - Arthritis & …, 2022 - Wiley Online Library
Objective Polygenic risk scores (PRS) allow risk stratification using common single‐
nucleotide polymorphisms (SNPs), and clinical applications are currently explored for …
nucleotide polymorphisms (SNPs), and clinical applications are currently explored for …