Osteoarthritis (OA) is a common degenerative disease characterized by the destruction of
articular cartilage and chronic inflammation of surrounding tissues. Matrix metalloproteinase …

Osteoarthritis (OA) is a type of joint disease associated with wear and tear, inflammation,
and aging. Mechanical stress along with synovial inflammation promotes the degradation of …

Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage
degradation but also synovial membrane inflammation, osteophyte formation and …

The hyaline cartilage is the most abundant type of cartilage in the body. It is responsible for
the bone formation in the embryo (endochondral ossification) and in adults, it can be found …

Chondrogenesis occurs as a result of mesenchymal cell condensation and
chondroprogenitor cell differentiation. Following chondrogenesis, the chondrocytes remain …

Highlights•Different OA etiologies present a challenge for developing a single targeted
therapy.•Common mechanisms occur in inflammatory, mechanical, and oxidative stress in …

In adult healthy cartilage, chondrocytes are in a quiescent phase characterized by a fine
balance between anabolic and catabolic activities. In ageing, degenerative joint diseases …

Osteoarthritis (OA) is a degenerative whole joint disease, for which no preventative or
therapeutic biological interventions are available. This is likely due to the fact that OA …

Osteoarthritis (OA) is the most common form of arthritis, is the leading cause of impaired
mobility in the elderly, and accounts for more than a third of chronic moderate to severe pain …

The role of DNA methylation in the regulation of catabolic genes such as MMP13 and IL1B,
which have sparse CpG islands, is poorly understood in the context of musculoskeletal …