Transcriptional regulation is essential for the correct functioning of cells during development
and in postnatal life. The basic Helix-loop-Helix (bHLH) superfamily of transcription factors is …

Directed neuronal differentiation of human pluripotent stem cells (hPSCs), neural
progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly …

The formation of functional neural circuits in the vertebrate central nervous system (CNS)
requires that appropriate numbers of the correct types of neuronal and glial cells are …

The cerebral neocortex is segregated into six horizontal layers, each containing unique
populations of molecularly and functionally distinct excitatory projection (pyramidal) neurons …

Radial glia cells function as neural stem cells in the developing brain and generate self-
renewing and differentiating daughter cells by asymmetric cell divisions. During these …

Proneural genes such as Ascl1 are known to promote cell cycle exit and neuronal
differentiation when expressed in neural progenitor cells. The mechanisms by which …

The correct positioning of neurons during development—achieved through directed
migration—is the basis for proper brain function. Several decades of research have yielded …

Advances in cellular reprogramming and stem cell differentiation now enable ex vivo studies
of human neuronal differentiation. However, it remains challenging to elucidate the …

In spite of the extensive potential of human mesenchymal stem cells (hMSCs) in cell therapy,
little is known about the molecular mechanisms that regulate their therapeutic properties. We …

Survival and integration of new neurons in the hippocampal circuit are rate-limiting steps in
adult hippocampal neurogenesis. Neuronal network activity is a major regulator of these …