Protein post‐translational modifications (PTM s) allow the cell to regulate protein activity and
play a crucial role in the response to changes in external conditions or internal states …

Short sequence motifs are ubiquitous across the three major types of biomolecules:
hundreds of classes and thousands of instances of DNA regulatory elements, RNA motifs …

SH3 domains are protein modules that mediate protein-protein interactions in many
eukaryotic signal transduction pathways. The majority of SH3 domains studied thus far act …

The human proteome contains a plethora of short linear motifs (SLiMs) that serve as binding
interfaces for modular protein domains. Such interactions are crucial for signaling and other …

A growing body of work suggests that the material properties of biomolecular condensates
ensuing from liquid–liquid phase separation change with time. How this aging process is …

The past decade has witnessed exponential growth in the generation of high-throughput
human data across almost all known dimensions of biological systems. The discipline of …

Biological processes are dynamically regulated by signaling networks composed of protein
kinases and phosphatases. Calcineurin, or PP3, is a conserved phosphoserine …

Protein–protein interactions (PPIs) between modular binding domains and their target
peptide motifs are thought to largely depend on the intrinsic binding specificities of the …

Protein phosphorylation plays a central role in creating a highly dynamic network of
interacting proteins that reads and responds to signals from growth factors in the cellular …

The assembly of complexes following the detection of extracellular signals is often controlled
by signaling proteins comprising multiple peptide binding modules. The SRC homology …