Eukaryotic genomes are organized into domains containing individual genes and gene
clusters that have distinct patterns of expression both during development and in …

The SET domain is a 130-amino acid, evolutionarily conserved sequence motif present in
chromosomal proteins that function in modulating gene activities from yeast to mammals …

Interphase chromatin is organized into topologically associating domains (TADs). Within
TADs, chromatin looping interactions are formed between DNA regulatory elements, but …

An insulator is a DNA sequence that can act as a barrier to the influences of neighboring cis-
acting elements, preventing gene activation, for example, when located between an …

Members of the small Maf family (MafK, MafF, and MafG) are basic region leucine zipper
(bZip) proteins that can function as transcriptional activators or repressors. The dimer …

The AT-hook is a small DNA-binding protein motif which was first described in the high
mobility group non-histone chromosomal protein HMG-I (Y). Since its discovery, this motif …

Insulators are DNA sequences that control the interactions among genomic regulatory
elements and act as chromatin boundaries. A thorough understanding of their location and …

The 1.2-kb DNA sequence element (5′ HS4) at the 5′ end of the chicken β-globin locus
has the two defining properties of an insulator: it prevents an “external” enhancer from acting …

Virtually all diffuse large cell lymphomas and a significant fraction of follicular lymphomas
contain translocations and/or point mutations in the 5′ non-coding region of the putative …

Insulators mark the boundaries of chromatin domains by limiting the range of action of
enhancers and silencers. Although the properties of insulators have been well studied, their …