Green chemistry in the synthesis of pharmaceuticals

S Kar, H Sanderson, K Roy, E Benfenati… - Chemical …, 2021 - ACS Publications
The principles of green chemistry (GC) can be comprehensively implemented in green
synthesis of pharmaceuticals by choosing no solvents or green solvents (preferably water) …

3d transition metals for C–H activation

P Gandeepan, T Müller, D Zell, G Cera… - Chemical …, 2018 - ACS Publications
C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with
notable applications to material sciences, crop protection, drug discovery, and …

3d metallaelectrocatalysis for resource economical syntheses

P Gandeepan, LH Finger, TH Meyer… - Chemical Society …, 2020 - pubs.rsc.org
Resource economy constitutes one of the key challenges for researchers and practitioners
in academia and industries, in terms of rising demand for sustainable and green synthetic …

Resource economy by metallaelectrocatalysis: merging electrochemistry and CH activation

TH Meyer, LH Finger, P Gandeepan, L Ackermann - Trends in Chemistry, 2019 - cell.com
Oxidative CH activation has emerged as an increasingly powerful tool in molecular
syntheses. Despite major progress towards atom and step economy, these transformations …

Green strategies for transition metal-catalyzed C–H activation in molecular syntheses

U Dhawa, N Kaplaneris, L Ackermann - Organic Chemistry Frontiers, 2021 - pubs.rsc.org
Transition metal catalyzed C–H activation has surfaced as a powerful tool to improve the
efficacy of molecular synthesis. Last two decades have witnessed a considerable progress …

C–H functionalization reactions under flow conditions

S Santoro, F Ferlin, L Ackermann… - Chemical Society Reviews, 2019 - pubs.rsc.org
C–H functionalization technologies have progressed enormously in the last decade as
testified by the great number of publications that have appeared in the literature, which are …

Cobalt‐Catalyzed Oxidative C− H Activation: Strategies and Concepts

R Mei, U Dhawa, RC Samanta, W Ma… - …, 2020 - Wiley Online Library
Inexpensive cobalt‐catalyzed oxidative C− H functionalization has emerged as a powerful
tool for the construction of C− C and C− Het bonds, which offers unique potential for …

Biomass-derived solvents for sustainable transition metal-catalyzed C–H activation

P Gandeepan, N Kaplaneris, S Santoro… - ACS Sustainable …, 2019 - ACS Publications
Transition metal-catalyzed C–H activation has emerged as an increasingly powerful strategy
in molecular syntheses and a particularly attractive alternative to classical methods of cross …

Classic vs. C–H functionalization strategies in the synthesis of APIs: a sustainability comparison

F Ferlin, G Brufani, G Rossini, L Vaccaro - Green Chemistry, 2023 - pubs.rsc.org
The landscape of organic synthesis has changed in the last two decades, especially in
areas such as pharmaceutical synthesis and large-scale industrial synthesis. The progress …

Allenes for versatile iron-catalyzed C–H activation by weak O-coordination: mechanistic insights by kinetics, intermediate isolation, and computation

AM Messinis, LH Finger, L Hu… - Journal of the American …, 2020 - ACS Publications
The iron-catalyzed hydroarylation of allenes was accomplished by weak phenone
assistance. The C–H activation proceeded with excellent efficacy and high ortho …