The prevalence of obesity, measured by body mass index, has risen to unacceptable levels
in both men and women in the United States and worldwide with resultant hazardous health …

Background Reducing saturated fat reduces serum cholesterol, but effects on other
intermediate outcomes may be less clear. Additionally, it is unclear whether the energy from …

The specific metabolic contribution of consuming different energy-yielding macronutrients
(namely, carbohydrates, protein and lipids) to obesity is a matter of active debate. In this …

Despite considerable advances in the past few years, obesity and type 2 diabetes mellitus
(T2DM) remain two major challenges for public health systems globally. In the past 9 years …

The rapid rise of obesity during the past decades has coincided with a profound shift of our
living environment, including unhealthy dietary patterns, a sedentary lifestyle, and physical …

Molecular clocks in the periphery coordinate tissue-specific daily biorhythms by integrating
input from the hypothalamic master clock and intracellular metabolic signals. One such key …

Obesity, a major public health concern, is a multifactorial disease caused by both
environmental and genetic factors. Although recent genome-wide association studies have …

Type 2 diabetes mellitus, obesity and metabolic syndrome are becoming more prevalent
worldwide and will present an increasingly challenging burden on healthcare systems …

As obesity has become a major global public health challenge, a large number of studies
have analyzed different strategies aimed at inducing a negative energy balance and …

Over the past decade, a large body of literature has demonstrated that disruptions of the
endogenous circadian clock, whether environmental or genetic, lead to metabolic …