Mitochondria are crucial organelles as their role in cellular energy production of eukaryotes.
Because the brain cells demand high energy for maintaining their normal activities …

Melatonin is synthesized by several tissues besides the pineal gland, and beyond its
regulatory effects in light‐dark cycle, melatonin is a hormone with neuroprotective, anti …

Parkinson's disease (PD) is a common age-related neurodegenerative movement disorder,
which is mainly due to the loss of dopaminergic neurons. Pyroptosis is a new programmed …

Autophagy is involved in the pathogenesis of neurodegenerative diseases including
Parkinson disease (PD). However, little is known about the regulation of autophagy in …

Animal models are widely used to study alterations caused by Parkinson's disease (PD).
However, in general, pharmacological models do not express the progressive nature of the …

Tyrosine hydroxylase (TH) is the rate-limiting enzyme in brain catecholamine biosynthesis,
and tetrahydrobiopterin is its cofactor. Research has focused on identifying mechanisms of …

Parkinson׳ s disease (PD) is a neurodegenerative disorder characterized by a progressive
loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Systemic and …

Neurodegenerative diseases are typified by neuronal loss associated with progressive
dysfunction and clinical presentation. Neurodegenerative diseases are characterized by the …

Parkinson's disease (PD) is a chronic neurodegenerative disorder characterized by
progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) …

Neuronal oxidative stress and mitochondrial dysfunction have been implicated in
Parkinson's disease. Melatonin is a natural antioxidant and free radical scavenger that has …