The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

Rho GTPases regulate cytoskeletal and cell adhesion dynamics and thereby coordinate a
wide range of cellular processes, including cell migration, cell polarity and cell cycle …

Cell migration is an essential process, both in unicellular organisms such as amoeba and as
individual or collective motility in highly developed multicellular organisms like mammals. It …

Migration is a polarized cellular process that opposes a protrusive front edge to a retracting
trailing edge. From the front to the rear, actin-mediated forces sequentially promote cell …

Pyrin, encoded by the MEFV gene, is an intracellular pattern recognition receptor that
assembles inflammasome complexes in response to pathogen infections. Mutations in the …

Many fundamental processes in cell biology are regulated by Rho GTPases, including cell
adhesion, migration and differentiation. While regulating cellular functions, members of the …

The actin and intermediate filament cytoskeletons contribute to numerous cellular
processes, including morphogenesis, cytokinesis and migration. These two cytoskeletal …

Malignant carcinomas are often characterized by metastasis, the movement of carcinoma
cells from a primary site to colonize distant organs. For metastasis to occur, carcinoma cells …

The p21 activated kinases (Paks) are well known effector proteins for the Rho GTPases
Cdc42 and Rac. The Paks contain 6 members, which fall into 2 families of proteins. The first …

The RhoA GTPase plays a vital role in assembly of contractile actin-myosin filaments (stress
fibers) and of associated focal adhesion complexes of adherent monolayer cells in culture …