Every day, analytical and bio-analytical chemists make sustained efforts to improve the
sensitivity, specificity, robustness, and reproducibility of their methods. Especially in targeted …

Abstract Alzheimer's disease (AD), the most common form of dementia, remains challenging
to understand and treat despite decades of research and clinical investigation. This might be …

Plasma and serum are rich sources of information regarding an individual's health state, and
protein tests inform medical decision making. Despite major investments, few new …

Proteomics is the large-scale study of the structure and function of proteins in complex
biological sample. Such an approach has the potential value to understand the complex …

Specimen collection is an integral component of clinical research. Specimens from subjects
with various stages of cancers or other conditions, as well as those without disease, are …

Human biospecimens are subject to a number of different collection, processing, and
storage factors that can significantly alter their molecular composition and consistency …

Clinical trials with antiangiogenic agents have not been able to validate plasma or serum
levels of angiogenesis regulators as reliable markers of cancer presence or therapeutic …

Background Blood phosphorylated tau (p-tau) forms are promising Alzheimer's disease (AD)
biomarkers, but validation in matrices other than ethylenediaminetetraacetic acid (EDTA) …

Human biospecimens are subject to a number of different collection, processing, and
storage factors that can significantly alter their molecular composition and consistency …

Background: This report and a companion report describe a validation of the ability of serum
proteomic profiling via SELDI-TOF mass spectrometry to detect prostatic cancer. Details of …