The cerebral cortex constitutes more than half the volume of the human brain and is
presumed to be responsible for the neuronal computations underlying complex phenomena …

The human CNS follows a pattern of development typical of all mammals, but certain
neurodevelopmental features are highly derived. Building the human CNS requires the …

Disorders of the nervous system are challenging to study and treat due to the relative
inaccessibility of functional human brain tissue for research. Stem cell-derived 3D human …

The human cerebral cortex is vastly expanded relative to other primates and
disproportionately occupied by distributed association regions. Here we offer a hypothesis …

The SOX proteins belong to the superfamily of transcription factors (TFs) that display
properties of both classical TFs and architectural components of chromatin. Since the …

To understand the emergence of human higher cognition, we must understand its biological
substrate—the cerebral cortex, which considers itself the crowning achievement of evolution …

The human brain develops slowly and over a long period of time which lasts for almost three
decades. This enables good spatio-temporal resolution of histogenetic and neurogenetic …

Subplate neurons have an essential role in cortical circuit formation. They are among the
earliest formed neurons of the cerebral cortex, are located at the junction of white and grey …

The ability to stop already-initiated actions is a key cognitive control ability. Recent work on
human action-stopping has been dominated by two controversial debates. First, the …

Somatic mutations occur during brain development and are increasingly implicated as a
cause of neurogenetic disease. However, the patterns in which somatic mutations distribute …