Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation

Y Jiang, Y Chen, Z Song, Z Tan, J Cheng - Advanced Drug Delivery …, 2021 - Elsevier
The recent outbreaks of infectious diseases caused by multidrug-resistant pathogens have
sounded a piercing alarm for the need of new effective antimicrobial agents to guard public …

[HTML][HTML] Therapeutic strategies against bacterial biofilms

Y Bi, G Xia, C Shi, J Wan, L Liu, Y Chen, Y Wu… - Fundamental …, 2021 - Elsevier
The emergence of multi-drug resistance makes bacterial infection a major threat to public
health and economy. The formation of bacterial biofilms is one of the main reasons of …

Host defense peptide mimicking antimicrobial amino acid polymers and beyond: Design, synthesis and biomedical applications

Y Wu, K Chen, J Wang, M Chen, Y Chen, Y She… - Progress in Polymer …, 2023 - Elsevier
Microbial infections endanger human health and life. Conventional antibiotics has saved
countless human lives, however, is seriously challenged by the quick emergence of …

Short guanidinium‐functionalized poly (2‐oxazoline) s displaying potent therapeutic efficacy on drug‐resistant fungal infections

W Jiang, M Zhou, Z Cong, J Xie, W Zhang… - Angewandte …, 2022 - Wiley Online Library
New antifungals are urgently needed to combat invasive fungal infections, due to limited
types of available antifungal drugs and frequently encountered side effects, as well as the …

Synthetic polypeptide polymers as simplified analogues of antimicrobial peptides

P Salas-Ambrosio, A Tronnet, P Verhaeghe… - …, 2020 - ACS Publications
Antimicrobial peptides (AMPs) are naturally occurring macromolecules made of amino acids
that are potent broad-spectrum antibiotics with potential as novel therapeutic agents. This …

Synthetic macromolecules as therapeutics that overcome resistance in cancer and microbial infection

J Tan, J Tay, J Hedrick, YY Yang - Biomaterials, 2020 - Elsevier
Synthetic macromolecular antimicrobials have shown efficacy in the treatment of multidrug
resistant (MDR) pathogens. These synthetic macromolecules, inspired by Nature's …

Peptide-mimicking poly (2-oxazoline) s possessing potent antifungal activity and BBB penetrating property to treat invasive infections and meningitis

W Jiang, M Zhou, S Chen, J Xie, M Chen… - Journal of the …, 2023 - ACS Publications
Invasive fungal infections, including meningitis, cause a high mortality rate due to few
available antifungal drugs and frequently associated side effects and quick emergence of …

[HTML][HTML] Effective and biocompatible antibacterial surfaces via facile synthesis and surface modification of peptide polymers

Z Lu, Y Wu, Z Cong, Y Qian, X Wu, N Shao, Z Qiao… - Bioactive materials, 2021 - Elsevier
It is an urgent need to tackle drug-resistance microbial infections that are associated with
implantable biomedical devices. Host defense peptide-mimicking polymers have been …

A dual-functional implant with an enzyme-responsive effect for bacterial infection therapy and tissue regeneration

Y Ding, Y Hao, Z Yuan, B Tao, M Chen, C Lin… - Biomaterials …, 2020 - pubs.rsc.org
Biomaterial-associated bacterial infection is one of the major causes of implant failure. The
treatment of such an implant infection typically requires the elimination of bacteria and …

Bioswitchable antibacterial coatings enable self‐sterilization of implantable healthcare dressings

A Wang, S Duan, X Ding, N Zhao, Y Hu… - Advanced Functional …, 2021 - Wiley Online Library
Healthcare‐acquired bacterial infections are a threat to public health. Therefore,
development of self‐sterilizing implantable dressing materials is in increasing demand …