Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation
The recent outbreaks of infectious diseases caused by multidrug-resistant pathogens have
sounded a piercing alarm for the need of new effective antimicrobial agents to guard public …
sounded a piercing alarm for the need of new effective antimicrobial agents to guard public …
[HTML][HTML] Therapeutic strategies against bacterial biofilms
The emergence of multi-drug resistance makes bacterial infection a major threat to public
health and economy. The formation of bacterial biofilms is one of the main reasons of …
health and economy. The formation of bacterial biofilms is one of the main reasons of …
Host defense peptide mimicking antimicrobial amino acid polymers and beyond: Design, synthesis and biomedical applications
Microbial infections endanger human health and life. Conventional antibiotics has saved
countless human lives, however, is seriously challenged by the quick emergence of …
countless human lives, however, is seriously challenged by the quick emergence of …
Short guanidinium‐functionalized poly (2‐oxazoline) s displaying potent therapeutic efficacy on drug‐resistant fungal infections
New antifungals are urgently needed to combat invasive fungal infections, due to limited
types of available antifungal drugs and frequently encountered side effects, as well as the …
types of available antifungal drugs and frequently encountered side effects, as well as the …
Synthetic polypeptide polymers as simplified analogues of antimicrobial peptides
P Salas-Ambrosio, A Tronnet, P Verhaeghe… - …, 2020 - ACS Publications
Antimicrobial peptides (AMPs) are naturally occurring macromolecules made of amino acids
that are potent broad-spectrum antibiotics with potential as novel therapeutic agents. This …
that are potent broad-spectrum antibiotics with potential as novel therapeutic agents. This …
Synthetic macromolecules as therapeutics that overcome resistance in cancer and microbial infection
Synthetic macromolecular antimicrobials have shown efficacy in the treatment of multidrug
resistant (MDR) pathogens. These synthetic macromolecules, inspired by Nature's …
resistant (MDR) pathogens. These synthetic macromolecules, inspired by Nature's …
Peptide-mimicking poly (2-oxazoline) s possessing potent antifungal activity and BBB penetrating property to treat invasive infections and meningitis
Invasive fungal infections, including meningitis, cause a high mortality rate due to few
available antifungal drugs and frequently associated side effects and quick emergence of …
available antifungal drugs and frequently associated side effects and quick emergence of …
[HTML][HTML] Effective and biocompatible antibacterial surfaces via facile synthesis and surface modification of peptide polymers
It is an urgent need to tackle drug-resistance microbial infections that are associated with
implantable biomedical devices. Host defense peptide-mimicking polymers have been …
implantable biomedical devices. Host defense peptide-mimicking polymers have been …
A dual-functional implant with an enzyme-responsive effect for bacterial infection therapy and tissue regeneration
Y Ding, Y Hao, Z Yuan, B Tao, M Chen, C Lin… - Biomaterials …, 2020 - pubs.rsc.org
Biomaterial-associated bacterial infection is one of the major causes of implant failure. The
treatment of such an implant infection typically requires the elimination of bacteria and …
treatment of such an implant infection typically requires the elimination of bacteria and …
Bioswitchable antibacterial coatings enable self‐sterilization of implantable healthcare dressings
Healthcare‐acquired bacterial infections are a threat to public health. Therefore,
development of self‐sterilizing implantable dressing materials is in increasing demand …
development of self‐sterilizing implantable dressing materials is in increasing demand …