Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …

The Hippo pathway is an evolutionarily conserved signalling pathway with key roles in
organ development, epithelial homeostasis, tissue regeneration, wound healing and …

Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …

Polyphenolic materials are a class of fascinating and versatile bioinspired materials for
biointerfacial engineering. In particular, due to the presence of active chemical groups, a …

The Hippo signalling pathway has emerged as a major player in many aspects of liver
biology, such as development, cell fate determination, homeostatic function and …

Biophysical cues, such as mechanical properties, play a critical role in tissue growth and
homeostasis. During organ development and tissue injury repair, compressive and tensional …

Lungs undergo mechanical strain during breathing, but how these biophysical forces affect
cell fate and tissue homeostasis are unclear. We show that biophysical forces through …

Tissues consist of cells and their surrounding extracellular matrix (ECM). Cell–ECM
interactions play crucial roles in embryonic development, differentiation, tissue remodeling …

Mechanical hallmarks of fibrotic microenvironments are both outcomes and causes of
fibrosis progression. Understanding how cells sense and transmit mechanical cues in the …

The term 'fibroblast'often serves as a catch-all for a diverse array of mesenchymal cells,
including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …