Calcium (Ca2+) is a major second messenger in cells and is essential for the fate and
survival of all higher organisms. Different Ca2+ channels, pumps, or exchangers regulate …

Mitochondria are dynamic organelles that undergo fusion and fission. These active
processes occur continuously and simultaneously and are mediated by nuclear-DNA …

Autophagy is a process of intracellular self-recycling and degradation that plays an
important role in maintaining cell homeostasis. However, the molecular mechanism of …

The endoplasmic reticulum (ER) and mitochondria are interconnected intracellular
organelles with vital roles in the regulation of cell signaling and function. While the ER …

Mitochondria are highly dynamic organelles beyond powerhouses of a cell. These
components also play important roles in cell homeostasis by regulating cell function and …

The endoplasmic reticulum (ER) is an organelle that is responsible for many essential
subcellular processes. Interconnected narrow tubules at the periphery and thicker sheet-like …

High-resolution 3D images of organelles are of paramount importance in cellular biology.
Although light microscopy and transmission electron microscopy (TEM) have provided the …

Background: The continued success of oncological therapeutics is dependent on the
mitigation of treatment-related adverse events, particularly cardiovascular toxicities. As such …

Organelles form tight connections through membrane contact sites, thereby cooperating to
regulate homeostasis and cell function. Among them, the contact between endoplasmic …

In eukaryotic cells, organelles could coordinate complex mechanisms of signaling
transduction metabolism and gene expression through their functional interactions. The …