[HTML][HTML] Molecular mechanisms of membrane targeting antibiotics
RM Epand, C Walker, RF Epand… - Biochimica et Biophysica …, 2016 - Elsevier
The bacterial membrane provides a target for antimicrobial peptides. There are two groups
of bacteria that have characteristically different surface membranes. One is the Gram …
of bacteria that have characteristically different surface membranes. One is the Gram …
Concepts and methods of solid-state NMR spectroscopy applied to biomembranes
TR Molugu, S Lee, MF Brown - Chemical reviews, 2017 - ACS Publications
Concepts of solid-state NMR spectroscopy and applications to fluid membranes are
reviewed in this paper. Membrane lipids with 2H-labeled acyl chains or polar head groups …
reviewed in this paper. Membrane lipids with 2H-labeled acyl chains or polar head groups …
[HTML][HTML] The 2018 biomembrane curvature and remodeling roadmap
P Bassereau, R Jin, T Baumgart… - Journal of physics D …, 2018 - iopscience.iop.org
The importance of curvature as a structural feature of biological membranes has been
recognized for many years and has fascinated scientists from a wide range of different …
recognized for many years and has fascinated scientists from a wide range of different …
[HTML][HTML] Physical properties of model biological lipid bilayers: insights from all-atom molecular dynamics simulations
The physical properties of lipid bilayers are sensitive to the specific type and composition of
the lipids that make up the many different types of cell membranes. Studying model bilayers …
the lipids that make up the many different types of cell membranes. Studying model bilayers …
Structure and function in antimicrobial piscidins: histidine position, directionality of membrane insertion, and pH-dependent permeabilization
Piscidins are histidine-enriched antimicrobial peptides that interact with lipid bilayers as
amphipathic α-helices. Their activity at acidic and basic pH in vivo makes them promising …
amphipathic α-helices. Their activity at acidic and basic pH in vivo makes them promising …
Nonadditive compositional curvature energetics of lipid bilayers
The unique properties of the individual lipids that compose biological membranes together
determine the energetics of the surface. The energetics of the surface, in turn, govern the …
determine the energetics of the surface. The energetics of the surface, in turn, govern the …
Effects of lipid composition on bilayer membranes quantified by all-atom molecular dynamics
W Ding, M Palaiokostas, W Wang… - The Journal of Physical …, 2015 - ACS Publications
Biological bilayer membranes typically contain varying amounts of lamellar and nonlamellar
lipids. Lamellar lipids, such as dioleoylphosphatidylcholine (DOPC), are defined by their …
lipids. Lamellar lipids, such as dioleoylphosphatidylcholine (DOPC), are defined by their …
[HTML][HTML] The Antimicrobial Peptide Human Beta-Defensin 2 Inhibits Biofilm Production of Pseudomonas aeruginosa Without Compromising Metabolic Activity
KR Parducho, B Beadell, TK Ybarra, M Bush… - Frontiers in …, 2020 - frontiersin.org
Biofilm production is a key virulence factor that facilitates bacterial colonization on host
surfaces and is regulated by complex pathways, including quorum sensing, that also control …
surfaces and is regulated by complex pathways, including quorum sensing, that also control …
A “tug of war” maintains a dynamic protein–membrane complex: molecular dynamics simulations of C-Raf RBD-CRD bound to K-Ras4B at an anionic membrane
Association of Raf kinase with activated Ras triggers downstream signaling cascades
toward regulating transcription in the cells' nucleus. Dysregulation of Ras–Raf signaling …
toward regulating transcription in the cells' nucleus. Dysregulation of Ras–Raf signaling …
[HTML][HTML] Simulations of membrane-disrupting peptides II: AMP piscidin 1 favors surface defects over pores
Antimicrobial peptides (AMPs) that disrupt bacterial membranes are promising therapeutics
against the growing number of antibiotic-resistant bacteria. The mechanism of membrane …
against the growing number of antibiotic-resistant bacteria. The mechanism of membrane …