Human immune diversity: from evolution to modernity
The extreme diversity of the human immune system, forged and maintained throughout
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …
A guide to systems-level immunomics
The immune system is highly complex and distributed throughout an organism, with
hundreds to thousands of cell states existing in parallel with diverse molecular pathways …
hundreds to thousands of cell states existing in parallel with diverse molecular pathways …
Systemic IL-15, IFN-γ, and IP-10/CXCL10 signature associated with effective immune response to SARS-CoV-2 in BNT162b2 mRNA vaccine recipients
C Bergamaschi, E Terpos, M Rosati, M Angel, J Bear… - Cell reports, 2021 - cell.com
Early responses to vaccination are important for shaping both humoral and cellular
protective immunity. Dissecting innate vaccine signatures may predict immunogenicity to …
protective immunity. Dissecting innate vaccine signatures may predict immunogenicity to …
Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
AC Aschenbrenner, M Mouktaroudi, B Krämer… - Genome medicine, 2021 - Springer
Abstract Background The SARS-CoV-2 pandemic is currently leading to increasing numbers
of COVID-19 patients all over the world. Clinical presentations range from asymptomatic …
of COVID-19 patients all over the world. Clinical presentations range from asymptomatic …
[HTML][HTML] Vaccination in the elderly: the challenge of immune changes with aging
The unprecedented increase of life expectancy challenges society to protect the elderly from
morbidity and mortality making vaccination a crucial mean to safeguard this population …
morbidity and mortality making vaccination a crucial mean to safeguard this population …
[HTML][HTML] The immunology of SARS-CoV-2 infections and vaccines
L Grigoryan, B Pulendran - Seminars in immunology, 2020 - Elsevier
Abstract SARS-CoV-2, the virus that causes COVID-19, emerged in late 2019, and was
declared a global pandemic on March 11th 2020. With over 50 million cases and 1.2 million …
declared a global pandemic on March 11th 2020. With over 50 million cases and 1.2 million …
The science and medicine of human immunology
B Pulendran, MM Davis - Science, 2020 - science.org
BACKGROUND The mammalian immune system is a remarkable sensory system for the
detection and neutralization of pathogens. History is replete with the devastating effects of …
detection and neutralization of pathogens. History is replete with the devastating effects of …
[HTML][HTML] Vaccine-associated enhanced disease: case definition and guidelines for data collection, analysis, and presentation of immunization safety data
FM Munoz, JP Cramer, CL Dekker, MZ Dudley… - Vaccine, 2021 - Elsevier
Abstract This is a Brighton Collaboration Case Definition of the term “Vaccine Associated
Enhanced Disease” to be utilized in the evaluation of adverse events following …
Enhanced Disease” to be utilized in the evaluation of adverse events following …
Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses
Abstract Systems vaccinology has defined molecular signatures and mechanisms of
immunity to vaccination. However, comparative analysis of immunity to different vaccines is …
immunity to vaccination. However, comparative analysis of immunity to different vaccines is …
Development and applications of viral vectored vaccines to combat zoonotic and emerging public health threats
Vaccination is arguably the most cost-effective preventative measure against infectious
diseases. While vaccines have been successfully developed against certain viruses (eg …
diseases. While vaccines have been successfully developed against certain viruses (eg …