In 2013, M. Lancaster described the first protocol to obtain human brain organoids. These
organoids, usually generated from human-induced pluripotent stem cells, can mimic the …

Plethora of research has shed light on the critical role of synaptic dysfunction in various
neurodegenerative disorders (NDDs), including Alzheimer's disease (AD), Parkinson's …

Microglia, the resident immune cells of the brain, play a complex role in health and disease.
They actively survey the brain parenchyma by physically interacting with other cells and …

Growing evidence suggests a remarkable diversity and complexity in the molecular
composition of synapses, forming the basis for the brain to execute complex behaviors …

Biological membranes are complex, heterogeneous, and dynamic systems that play roles in
the compartmentalization and protection of cells from the environment. It is still a challenge …

Significance Stimulated emission depletion (STED) microscopy has been used to address a
wide range of neurobiological questions in optically well-accessible samples, such as cell …

Recent work by our laboratory and others indicates that co-display of multiple antigens on
protein-based nanoparticles may be key to induce cross-reactive antibodies that provide …

Synapses are integral for healthy brain function and are becoming increasingly recognized
as key structures in the early stages of brain disease. Understanding the pathological …

The incidence of ischemic stroke (IS) is rising in tandem with the global aging population.
There is an urgent need to delve deeper into the pathological mechanisms and develop new …

The complexity of the brain organization and the unique architecture of neurons have
motivated neuroscientists to stay at the forefront of cellular microscopy and rapidly take …