Prostate cancer has become the second leading cancer in men worldwide. Androgen plays
an important role in normal functioning, development, and differentiation of the prostate, and …

The nuclear receptor (NR) superfamily consists of 48 members that are divided into seven
subfamilies. NRs are transcription factors that play an important role in a number of …

Introduction: Transforming growth factor-beta (TGFβ) signaling plays a vital role in lung
adenocarcinoma (LUAD) progression. However, the involvement of TGFβ-regulated long …

Cancer-related alterations of the p53 tetramerization domain (TD) abrogate wild-type (WT)
p53 function. They result in a protein that preferentially forms monomers or dimers, which …

Amine oxidase copper-containing 1 (AOC1) is considered an oncogene in many types of
tumors. Nevertheless, there have been no investigations of AOC1 and its regulatory …

Polycystic ovary syndrome (PCOS), characterized by the androgen excess and arrest of
antral follicles, is a common endocrine disorder among women lacking specific diagnostic …

In prostate cancer (PCa), and many other hormone-dependent cancers, there is clear
evidence for distorted transcriptional control as disease driver mechanisms. Defining which …

Prostate cancer biology is complex, and needs to be deciphered. The latest evidence
reveals the significant role of non-coding RNAs, particularly microRNAs (miRNAs), as key …

Dynamic studies in time course experimental designs and clinical approaches have been
widely used by the biomedical community. These applications are particularly relevant in …

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women. In PCOS,
insulin resistance and hyperandrogenism could drive the increased risk for cardiometabolic …