Collective cell migration results from the establishment and maintenance of collective
polarization, mechanocoupling, and cytoskeletal kinetics. The guidance of collective cell …

Evidence implicating Eph receptor tyrosine kinases and their ephrin ligands (that together
make up the 'Eph system') in cancer development and progression has been accumulating …

More than 25 years of research and preclinical validation have defined EphA2 receptor
tyrosine kinase as a promising molecular target for clinical translation in cancer treatment …

The e rythropoietin-p roducing h epatocellular carcinoma (Eph) receptor tyrosine kinase
family plays important roles in developmental processes, adult tissue homeostasis, and …

Eph receptors, the largest subfamily of receptor tyrosine kinases, are linked with proliferative
disease, such as cancer, as a result of their deregulated expression or mutation. Unlike …

Membrane-type matrix metalloproteases (MT-MMP) are pivotal regulators of cell invasion,
growth and survival. Tethered to the cell membranes by a transmembrane domain or GPI …

Apico-basal polarity is typical of cells present in differentiated epithelium while front-rear
polarity develops in motile cells. In cancer development, the transition from epithelial to …

Tumor targeting is a booming business: The global therapeutic monoclonal antibody market
accounted for more than $78 billion in 2012 and is expanding exponentially. Tumors can be …

Sarcomas are deadly malignant tumors of mesenchymal origin occurring at all ages. The
expression and function of the membrane-type matrix metalloproteinase MMP14 is closely …

Glioblastoma multiforme (GBM) is an intractable tumor despite therapeutic advances,
principally because of its invasive properties. Radiation is a staple in therapeutic regimens …