Collective cell migration: guidance principles and hierarchies
Collective cell migration results from the establishment and maintenance of collective
polarization, mechanocoupling, and cytoskeletal kinetics. The guidance of collective cell …
polarization, mechanocoupling, and cytoskeletal kinetics. The guidance of collective cell …
Eph receptors and ephrins in cancer progression
EB Pasquale - Nature Reviews Cancer, 2024 - nature.com
Evidence implicating Eph receptor tyrosine kinases and their ephrin ligands (that together
make up the 'Eph system') in cancer development and progression has been accumulating …
make up the 'Eph system') in cancer development and progression has been accumulating …
Oncogenic functions and therapeutic targeting of EphA2 in cancer
K Wilson, E Shiuan, DM Brantley-Sieders - Oncogene, 2021 - nature.com
More than 25 years of research and preclinical validation have defined EphA2 receptor
tyrosine kinase as a promising molecular target for clinical translation in cancer treatment …
tyrosine kinase as a promising molecular target for clinical translation in cancer treatment …
Eph receptors and ephrins: therapeutic opportunities
A Barquilla, EB Pasquale - Annual review of pharmacology and …, 2015 - annualreviews.org
The e rythropoietin-p roducing h epatocellular carcinoma (Eph) receptor tyrosine kinase
family plays important roles in developmental processes, adult tissue homeostasis, and …
family plays important roles in developmental processes, adult tissue homeostasis, and …
Eph receptor signalling: from catalytic to non-catalytic functions
Eph receptors, the largest subfamily of receptor tyrosine kinases, are linked with proliferative
disease, such as cancer, as a result of their deregulated expression or mutation. Unlike …
disease, such as cancer, as a result of their deregulated expression or mutation. Unlike …
[HTML][HTML] Membrane-type matrix metalloproteases as diverse effectors of cancer progression
SP Turunen, O Tatti-Bugaeva, K Lehti - Biochimica et Biophysica Acta (BBA …, 2017 - Elsevier
Membrane-type matrix metalloproteases (MT-MMP) are pivotal regulators of cell invasion,
growth and survival. Tethered to the cell membranes by a transmembrane domain or GPI …
growth and survival. Tethered to the cell membranes by a transmembrane domain or GPI …
[HTML][HTML] Cell polarity signaling in the plasticity of cancer cell invasiveness
A Gandalovičová, T Vomastek, D Rosel, J Brábek - Oncotarget, 2016 - ncbi.nlm.nih.gov
Apico-basal polarity is typical of cells present in differentiated epithelium while front-rear
polarity develops in motile cells. In cancer development, the transition from epithelial to …
polarity develops in motile cells. In cancer development, the transition from epithelial to …
Selecting targets for tumor imaging: an overview of cancer-associated membrane proteins
MC Boonstra, SWL De Geus… - Biomarkers in …, 2016 - journals.sagepub.com
Tumor targeting is a booming business: The global therapeutic monoclonal antibody market
accounted for more than $78 billion in 2012 and is expanding exponentially. Tumors can be …
accounted for more than $78 billion in 2012 and is expanding exponentially. Tumors can be …
MMP14 in sarcoma: a regulator of tumor microenvironment communication in connective tissues
Sarcomas are deadly malignant tumors of mesenchymal origin occurring at all ages. The
expression and function of the membrane-type matrix metalloproteinase MMP14 is closely …
expression and function of the membrane-type matrix metalloproteinase MMP14 is closely …
Inhibition of radiation-induced glioblastoma invasion by genetic and pharmacological targeting of MDA-9/Syntenin
TP Kegelman, B Wu, SK Das… - Proceedings of the …, 2017 - National Acad Sciences
Glioblastoma multiforme (GBM) is an intractable tumor despite therapeutic advances,
principally because of its invasive properties. Radiation is a staple in therapeutic regimens …
principally because of its invasive properties. Radiation is a staple in therapeutic regimens …