For two decades, diversity-oriented synthesis (DOS) has facilitated the assembly of small-
molecule libraries comprising a variety of complex molecular architectures. Here, we …

The past decade has witnessed the emergence of N-(acyloxy) phthalimides (NHPI esters)
and its derivatives at the forefront of synthetic methods facilitating the construction of diverse …

In recent years, photochemistry has been a highly active research field. This renaissance is
linked to the upsurge of photoredox catalysis, a versatile platform for synthetic …

Carboxylic acids, the most versatile and ubiquitous diversity input used in medicinal
chemistry for canonical polar bond constructions such as amide synthesis, can now be …

The Birch reduction is a powerful synthetic methodology that uses solvated electrons to
convert inert arenes to 1, 4-cyclohexadienes—valuable intermediates for building molecular …

One of the most oft-employed methods for C–C bond formation involving the coupling of
vinyl-halides with aldehydes catalyzed by Ni and Cr (Nozaki–Hiyama–Kishi, NHK) has been …

Historically accessed through two-electron, anionic chemistry, ketones, alcohols, and
amines are of foundational importance to the practice of organic synthesis. After placing this …

Isomerization-based strategies to enable the stereodivergent construction of complex
polyenes from geometrically defined alkene linchpins remain conspicuously …

The addition of alkyl fragments to aliphatic aldehydes is a highly desirable transformation for
fragment couplings, yet existing methods come with operational challenges related to the …

A simple electrochemically mediated method for the conversion of alkyl carboxylic acids to
their borylated congeners is presented. This protocol features an undivided cell setup with …