Clostridium difficile is a major cause of intestinal infection and diarrhoea in individuals
following antibiotic treatment. Recent studies have begun to elucidate the mechanisms that …

There is an immediate need to drastically reduce the emissions associated with global fossil
fuel consumption in order to limit climate change. However, carbon-based materials …

Clostridium difficile infection (CDI) has significant clinical impact especially on the elderly
and/or immunocompromised patients. The pathogenicity of Clostridium difficile is mainly …

Clostridium difficile infection (CDI) is the leading cause of antimicrobial and health care-
associated diarrhea in humans, presenting a significant burden to global health care …

The outer surface of many archaea and bacteria is coated with a proteinaceous surface
layer (known as an S-layer), which is formed by the self-assembly of monomeric proteins …

Large clostridial toxins (LCTs) are a family of bacterial exotoxins that infiltrate and destroy
target cells. Members of the LCT family include Clostridioides difficile toxins TcdA and TcdB …

Application of CRISPR-Cas9 systems has revolutionized genome editing across all domains
of life. Here we report implementation of the heterologous Type II CRISPR-Cas9 system in …

The pathogenic clostridia cause many human and animal diseases, which typically arise as
a consequence of the production of potent exotoxins. Among the enterotoxic clostridia …

The worldwide emergence of epidemic strains of Clostridium difficile linked to increased
disease severity and mortality has resulted in greater research efforts toward determining …

Background. Despite substantial interest in biomarkers, their impact on clinical outcomes
and variation with bacterial strain has rarely been explored using integrated databases …